Literature DB >> 26995546

Overview of Transgenic Glioblastoma and Oligoastrocytoma CNS Models and Their Utility in Drug Discovery.

Fuyi Chen1,2, Albert Becker3, Joseph LoTurco1.   

Abstract

Many animal models have been developed to investigate the sources of central nervous system (CNS) tumor heterogeneity. Reviewed in this unit is a recently developed CNS tumor model using the piggyBac transposon system delivered by in utero electroporation, in which sources of tumor heterogeneity can be conveniently studied. Their applications for studying CNS tumors and drug discovery are also reviewed. © 2016 by John Wiley & Sons, Inc.
Copyright © 2016 John Wiley & Sons, Inc.

Entities:  

Keywords:  anaplastic oligoastrocytoma; atypical teratoid rhabdoid tumor; central nervous system; glioblastoma multiforme; in utero electroporation; piggyBac transposon; tumor heterogeneity

Mesh：

Year:  2016        PMID： 26995546      PMCID： PMC5043528          DOI： 10.1002/0471141755.ph1437s72

Source DB:  PubMed          Journal:  Curr Protoc Pharmacol        ISSN： 1934-8282


  73 in total

1.  An Flp indicator mouse expressing alkaline phosphatase from the ROSA26 locus.

Authors:  R Awatramani; P Soriano; J J Mai; S Dymecki
Journal:  Nat Genet       Date:  2001-11       Impact factor: 38.330

2.  Whole-body optical imaging of green fluorescent protein-expressing tumors and metastases.

Authors:  M Yang; E Baranov; P Jiang; F X Sun; X M Li; L Li; S Hasegawa; M Bouvet; M Al-Tuwaijri; T Chishima; H Shimada; A R Moossa; S Penman; R M Hoffman
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-01       Impact factor: 11.205

3.  Targeted gene delivery to telencephalic inhibitory neurons by directional in utero electroporation.

Authors:  Víctor Borrell; Yumiko Yoshimura; Edward M Callaway
Journal:  J Neurosci Methods       Date:  2004-12-02       Impact factor: 2.390

4.  ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice.

Authors:  Al Charest; Erik W Wilker; Margaret E McLaughlin; Keara Lane; Ram Gowda; Shanie Coven; Kevin McMahon; Steven Kovach; Yun Feng; Michael B Yaffe; Tyler Jacks; David Housman
Journal:  Cancer Res       Date:  2006-08-01       Impact factor: 12.701

5.  Essential role for Ras signaling in glioblastoma maintenance.

Authors:  Sheri L Holmen; Bart O Williams
Journal:  Cancer Res       Date:  2005-09-15       Impact factor: 12.701

Review 6.  Intra-tumour heterogeneity: a looking glass for cancer?

Authors:  Andriy Marusyk; Vanessa Almendro; Kornelia Polyak
Journal:  Nat Rev Cancer       Date:  2012-04-19       Impact factor: 60.716

7.  Pten haploinsufficiency accelerates formation of high-grade astrocytomas.

Authors:  Chang-Hyuk Kwon; Dawen Zhao; Jian Chen; Sheila Alcantara; Yanjiao Li; Dennis K Burns; Ralph P Mason; Eva Y-H P Lee; Hong Wu; Luis F Parada
Journal:  Cancer Res       Date:  2008-05-01       Impact factor: 12.701

8.  Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma.

Authors:  Dominik Sturm; Hendrik Witt; Volker Hovestadt; Dong-Anh Khuong-Quang; David T W Jones; Carolin Konermann; Elke Pfaff; Martje Tönjes; Martin Sill; Sebastian Bender; Marcel Kool; Marc Zapatka; Natalia Becker; Manuela Zucknick; Thomas Hielscher; Xiao-Yang Liu; Adam M Fontebasso; Marina Ryzhova; Steffen Albrecht; Karine Jacob; Marietta Wolter; Martin Ebinger; Martin U Schuhmann; Timothy van Meter; Michael C Frühwald; Holger Hauch; Arnulf Pekrun; Bernhard Radlwimmer; Tim Niehues; Gregor von Komorowski; Matthias Dürken; Andreas E Kulozik; Jenny Madden; Andrew Donson; Nicholas K Foreman; Rachid Drissi; Maryam Fouladi; Wolfram Scheurlen; Andreas von Deimling; Camelia Monoranu; Wolfgang Roggendorf; Christel Herold-Mende; Andreas Unterberg; Christof M Kramm; Jörg Felsberg; Christian Hartmann; Benedikt Wiestler; Wolfgang Wick; Till Milde; Olaf Witt; Anders M Lindroth; Jeremy Schwartzentruber; Damien Faury; Adam Fleming; Magdalena Zakrzewska; Pawel P Liberski; Krzysztof Zakrzewski; Peter Hauser; Miklos Garami; Almos Klekner; Laszlo Bognar; Sorana Morrissy; Florence Cavalli; Michael D Taylor; Peter van Sluis; Jan Koster; Rogier Versteeg; Richard Volckmann; Tom Mikkelsen; Kenneth Aldape; Guido Reifenberger; V Peter Collins; Jacek Majewski; Andrey Korshunov; Peter Lichter; Christoph Plass; Nada Jabado; Stefan M Pfister
Journal:  Cancer Cell       Date:  2012-10-16       Impact factor: 31.743

9.  Combinations of genetic mutations in the adult neural stem cell compartment determine brain tumour phenotypes.

Authors:  Thomas S Jacques; Alexander Swales; Monika J Brzozowski; Nico V Henriquez; Jacqueline M Linehan; Zaman Mirzadeh; Catherine O' Malley; Heike Naumann; Arturo Alvarez-Buylla; Sebastian Brandner
Journal:  EMBO J       Date:  2009-11-19       Impact factor: 11.598

10.  Modeling Adult Gliomas Using RCAS/t-va Technology.

Authors:  Dolores Hambardzumyan; Nduka M Amankulor; Karim Y Helmy; Oren J Becher; Eric C Holland
Journal:  Transl Oncol       Date:  2009-05       Impact factor: 4.243
View more
  3 in total

1.  Cancer modeling by Transgene Electroporation in Adult Zebrafish (TEAZ).

Authors:  Scott J Callahan; Stephanie Tepan; Yan M Zhang; Helen Lindsay; Alexa Burger; Nathaniel R Campbell; Isabella S Kim; Travis J Hollmann; Lorenz Studer; Christian Mosimann; Richard M White
Journal:  Dis Model Mech       Date:  2018-09-27       Impact factor: 5.758

Review 2.  In Vivo and Ex Vivo Pediatric Brain Tumor Models: An Overview.

Authors:  Zhiqin Li; Sigrid A Langhans
Journal:  Front Oncol       Date:  2021-04-01       Impact factor: 6.244

3.  Daam2 driven degradation of VHL promotes gliomagenesis.

Authors:  Wenyi Zhu; Saritha Krishna; Cristina Garcia; Chia-Ching John Lin; Bartley D Mitchell; Kenneth L Scott; Carrie A Mohila; Chad J Creighton; Seung-Hee Yoo; Hyun Kyoung Lee; Benjamin Deneen
Journal:  Elife       Date:  2017-10-20       Impact factor: 8.140
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.