Literature DB >> 26995526

Two novel phenanthraquinones with anti-cancer activity isolated from Bletilla striata.

Aijing Sun1, Jieqing Liu2, Suqiu Pang1, Junsheng Lin2, Ruian Xu3.   

Abstract

7-Hydroxy-2-methoxy-phenanthrene-3,4-dione and 3',7',7-trihydroxy-2,2',4'-trimethoxy-[1,8'-biphenanthrene]-3,4-dione, two novel compounds and four known compounds were isolated from Bletilla striata. The structures of the compounds were established on the basis of extensive spectroscopic analysis. The two compounds exhibited antiproliferative effects using the MTT test; these effects may be due to cell cycle arrest and inducing ROS generation.
Copyright © 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Anti-tumor activity; Bletilla striata; Cell cycle arrest; Phenanthraquinone; Reactive oxygen species

Mesh：

Substances：

Year:  2016        PMID： 26995526     DOI： 10.1016/j.bmcl.2016.01.076

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

1.  Bioactive Bibenzyl Enantiomers From the Tubers of Bletilla striata.

Authors:  Mei Zhou; Sai Jiang; Changfen Chen; Jinyu Li; Huayong Lou; Mengyun Wang; Gezhou Liu; Hanfei Liu; Ting Liu; Weidong Pan
Journal:  Front Chem       Date:  2022-06-09       Impact factor: 5.545

2.  Antiproliferative and Proapoptotic Effects of Phenanthrene Derivatives Isolated from Bletilla striata on A549 Lung Cancer Cells.

Authors:  Fei Zhou; Rui Feng; Ou Dai; Lian Yang; Yu Liu; Yun-Cai Tian; Cheng Peng; Liang Xiong
Journal:  Molecules       Date:  2022-05-30       Impact factor: 4.927

3.  The anti-Staphylococcus aureus activity of the phenanthrene fraction from fibrous roots of Bletilla striata.

Authors:  Jing-Jing Guo; Bin-Ling Dai; Ni-Pi Chen; Li-Xia Jin; Fu-Sheng Jiang; Zhi-Shan Ding; Chao-Dong Qian
Journal:  BMC Complement Altern Med       Date:  2016-11-29       Impact factor: 3.659

4.  Chemical Constituents from the Aerial Parts of Cyrtopodium paniculatum.

Authors:  Florence Auberon; Opeyemi Joshua Olatunji; Gaëtan Herbette; Diamondra Raminoson; Cyril Antheaume; Beatriz Soengas; Frédéric Bonté; Annelise Lobstein
Journal:  Molecules       Date:  2016-10-24       Impact factor: 4.411

Review 5.  Chemical Constituents, Pharmacologic Properties, and Clinical Applications of Bletilla striata.

Authors:  Delin Xu; Yinchi Pan; Jishuang Chen
Journal:  Front Pharmacol       Date:  2019-11-01       Impact factor: 5.810

6.  Simultaneous Determination of Three Bioactive Constituents from Bletilla striata by UPLC-MS/MS and Application of the Technique to Pharmacokinetic Analyses.

Authors:  Hao Chen; Lin Zheng; Chao-Ye Mei; Zi-Peng Gong; Yong-Jun Li; Si-Ying Chen; Yan-Yu Lan; Yong-Lin Wang; Ai-Min Wang; Yue-Ting Li; Yong Huang
Journal:  Evid Based Complement Alternat Med       Date:  2019-10-21       Impact factor: 2.629

7.  Biological evaluation, molecular modeling and dynamics simulation of phenanthrenes isolated from Bletilla striata as butyrylcholinesterase inhibitors.

Authors:  Yi Liu; Yanbei Tu; Yunyao Kang; Chao Zhu; Chuanhai Wu; Gang Chen; Zerong Liu; Yanfang Li
Journal:  Sci Rep       Date:  2022-08-11       Impact factor: 4.996

8.  Validation of the Anticolitis Efficacy of the Jian-Wei-Yu-Yang Formula.

Authors:  Jing Yan; Yan Tang; Wei Yu; Lu Jiang; Chen Liu; Qi Li; Zhiqiang Zhang; Changlei Shao; Yang Zheng; Xihao Liu; Xincheng Liu
Journal:  Evid Based Complement Alternat Med       Date:  2022-08-31       Impact factor: 2.650

9.  De Novo assembly, characterization and development of EST-SSRs from Bletilla striata transcriptomes profiled throughout the whole growing period.

Authors:  Delin Xu; Hongbo Chen; Murat Aci; Yinchi Pan; Yanni Shangguan; Jie Ma; Lin Li; Gang Qian; Qianxing Wang
Journal:  PLoS One       Date:  2018-10-26       Impact factor: 3.240
  9 in total

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