Shinya Furukawa1, Takenori Sakai2, Tetsuji Niiya3, Hiroaki Miyaoka4, Teruki Miyake5, Shin Yamamoto5, Koutatsu Maruyama6, Keiko Tanaka7, Teruhisa Ueda8, Hidenori Senba9, Masamoto Torisu10, Hisaka Minami11, Morikazu Onji12, Takeshi Tanigawa6, Bunzo Matsuura13, Yoichi Hiasa5, Yoshihiro Miyake7. 1. Department of Epidemiology and Preventive Medicine, Ehime University Graduate School of Medicine, Ehime, Japan; Epidemiology and Medical Statistics Unit, Translational Research Center, Ehime University Hospital, Ehime, Japan. Electronic address: shinya.furukawa@gmail.com. 2. Department of Internal Medicine, Yawatahama General City Hospital, Ehime, Japan. 3. Department of Internal Medicine, Matsuyama Shimin Hospital, Ehime, Japan. 4. Department of Internal Medicine, Saiseikai Matsuyama Hospital, Ehime, Japan. 5. Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan. 6. Department of Public Health, Juntendo University School of Medicine, Tokyo, Japan. 7. Department of Epidemiology and Preventive Medicine, Ehime University Graduate School of Medicine, Ehime, Japan; Epidemiology and Medical Statistics Unit, Translational Research Center, Ehime University Hospital, Ehime, Japan. 8. Department of Internal Medicine, Ehime Prefectural Central Hospital, Ehime, Japan. 9. Department of Epidemiology and Preventive Medicine, Ehime University Graduate School of Medicine, Ehime, Japan. 10. Department of Internal Medicine, Saiseikai Saijo Hospital, Ehime, Japan. 11. Department of Internal Medicine, Ehime Niihama Hospital, Ehime, Japan. 12. Department of Internal Medicine, Saiseikai Imabari Hospital, Ehime, Japan. 13. Department of Lifestyle-related Medicine and Endocrinology, Ehime University Graduate School of Medicine, Ehime, Japan.
Abstract
OBJECTIVE: To evaluate the association between microvascular complications and nocturia among Japanese patients with type 2 diabetes mellitus. METHODS: Study subjects were 731 Japanese patients with type 2 diabetes mellitus. A self-administered questionnaire was used to collect information on the variables under study. Study subjects were considered to have nocturia if they answered "once or more" to the question: "How many times do you typically wake up to urinate from sleeping at night until waking in the morning?" Diabetic neuropathy was diagnosed if the patients showed two or more of the following three characteristics: neuropathic symptoms, the absence of the Achilles reflex, or abnormal vibration perception. Diabetic nephropathy was defined as positive when the estimated glomerular filtration rate was <30 mL/min/1.73 m(2) and/or the urine albumin-to-creatinine ratio was ≥34 mg/mmol creatinine. Several ophthalmology specialists were responsible for evaluating diabetic retinopathy. Adjustment was made for sex, age, body mass index, duration of diabetes mellitus, current smoking, current drinking, hypertension, stroke, ischemic heart disease, and glycated hemoglobin. RESULTS: The prevalence of nocturia was 80.4%. Diabetic retinopathy was independently positively associated with nocturia (adjusted odds ratio 2.39 [95% confidence interval: 1.08-6.11]). In contrast, diabetic nephropathy or diabetic neuropathy was not associated with nocturia. CONCLUSION: In Japanese patients with type 2 diabetes mellitus, only diabetic retinopathy was independently positively associated with nocturia.
OBJECTIVE: To evaluate the association between microvascular complications and nocturia among Japanese patients with type 2 diabetes mellitus. METHODS: Study subjects were 731 Japanese patients with type 2 diabetes mellitus. A self-administered questionnaire was used to collect information on the variables under study. Study subjects were considered to have nocturia if they answered "once or more" to the question: "How many times do you typically wake up to urinate from sleeping at night until waking in the morning?" Diabetic neuropathy was diagnosed if the patients showed two or more of the following three characteristics: neuropathic symptoms, the absence of the Achilles reflex, or abnormal vibration perception. Diabetic nephropathy was defined as positive when the estimated glomerular filtration rate was <30 mL/min/1.73 m(2) and/or the urine albumin-to-creatinine ratio was ≥34 mg/mmol creatinine. Several ophthalmology specialists were responsible for evaluating diabetic retinopathy. Adjustment was made for sex, age, body mass index, duration of diabetes mellitus, current smoking, current drinking, hypertension, stroke, ischemic heart disease, and glycated hemoglobin. RESULTS: The prevalence of nocturia was 80.4%. Diabetic retinopathy was independently positively associated with nocturia (adjusted odds ratio 2.39 [95% confidence interval: 1.08-6.11]). In contrast, diabetic nephropathy or diabetic neuropathy was not associated with nocturia. CONCLUSION: In Japanese patients with type 2 diabetes mellitus, only diabetic retinopathy was independently positively associated with nocturia.
Authors: S Furukawa; T Sakai; T Niiya; H Miyaoka; T Miyake; S Yamamoto; K Maruyama; T Ueda; H Senba; M Torisu; H Minami; M Onji; T Tanigawa; B Matsuura; Y Hiasa; Y Miyake Journal: Int J Impot Res Date: 2016-11-17 Impact factor: 2.896
Authors: Ching-Pyng Kuo; Shu-Hua Lu; Chien-Ning Huang; Wen-Chun Liao; Meng-Chih Lee Journal: Int J Environ Res Public Health Date: 2021-03-15 Impact factor: 3.390