Jianguang Ji1, Jan Sundquist2, Kristina Sundquist2. 1. Center for Primary Health Care Research, Lund University, Sweden. Electronic address: Jianguang.ji@med.lu.se. 2. Center for Primary Health Care Research, Lund University, Sweden; Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA, USA.
Abstract
BACKGROUND: It is widely believed that autoimmune diseases affect predominantly in women, but the available evidence came from case control study with potential selection and recall bias. We aimed to examine the gender-specific incidence of autoimmune diseases by using national wide registers in Sweden. METHODS: Swedish Hospital Discharge Register and Outpatient Register were used to identify a set of autoimmune diseases between 1987 and 2010. Gender-specific incidence rate was standardized directly according to the Swedish age distribution in 2000. RESULTS: A total of 403,757 individuals were diagnosed with autoimmune diseases between 1987 and 2010 in Sweden. The overall incidence of 32 autoimmune disease was 60% higher in women than men. Female predominance was noted in 18 specific diseases, whereas the rest of them showed no difference or male predominance. The age of onset was different between men and women in 27 autoimmune diseases. CONCLUSIONS: Our study suggested that the classical view of female predominance of autoimmune diseases may be far from striking than previously believed. Further studies are needed to examine whether there is true difference between men and women.
BACKGROUND: It is widely believed that autoimmune diseases affect predominantly in women, but the available evidence came from case control study with potential selection and recall bias. We aimed to examine the gender-specific incidence of autoimmune diseases by using national wide registers in Sweden. METHODS: Swedish Hospital Discharge Register and Outpatient Register were used to identify a set of autoimmune diseases between 1987 and 2010. Gender-specific incidence rate was standardized directly according to the Swedish age distribution in 2000. RESULTS: A total of 403,757 individuals were diagnosed with autoimmune diseases between 1987 and 2010 in Sweden. The overall incidence of 32 autoimmune disease was 60% higher in women than men. Female predominance was noted in 18 specific diseases, whereas the rest of them showed no difference or male predominance. The age of onset was different between men and women in 27 autoimmune diseases. CONCLUSIONS: Our study suggested that the classical view of female predominance of autoimmune diseases may be far from striking than previously believed. Further studies are needed to examine whether there is true difference between men and women.
Authors: Vanessa L Kronzer; Alex D Tarabochia; Angie S Lobo Romero; Nicholas Y Tan; Thomas J O'Byrne; Cynthia S Crowson; Tamiel N Turley; Elena Myasoedova; John M Davis; Claire E Raphael; Rajiv Gulati; Sharonne N Hayes; Marysia S Tweet Journal: J Am Coll Cardiol Date: 2020-11-10 Impact factor: 24.094
Authors: Zachary A Miller; Virginia E Sturm; Gamze Balci Camsari; Anna Karydas; Jennifer S Yokoyama; Lea T Grinberg; Adam L Boxer; Howard J Rosen; Katherine P Rankin; Maria Luisa Gorno-Tempini; Giovanni Coppola; Daniel H Geschwind; Rosa Rademakers; William W Seeley; Neill R Graff-Radford; Bruce L Miller Journal: Neurol Neuroimmunol Neuroinflamm Date: 2016-10-28