| Literature DB >> 26994842 |
Agnieszka Szymańska-Michalak1, Dariusz Wawrzyniak1, Grzegorz Framski1, Marta Kujda2, Paulina Zgoła1, Jacek Stawinski1, Jan Barciszewski1, Jerzy Boryski1, Adam Kraszewski3.
Abstract
New aromatic and aliphatic 3'-O-acyl-5-fluoro-2'-deoxyuridine derivatives were synthesized and evaluated as candidates for prodrugs against various cancer cell lines. As the most promising candidate for antimalignant therapeutics was found a dual-acting acyl derivative 7h, which apparently released not only the known anticancer nucleoside, 5-fluoro-2'-deoxyuridine (FdU), but also an additional active metabolite, acetylsalicylic acid, reinforcing thus therapeutic effect of FdU. Promising therapeutic indices showed also some aromatic dicarboxylic acids derivatives decorated with FdU esters (11 and 12).Entities:
Keywords: 5-fluoro-2′-deoxyuridine; Anticancer; Double barrelled; Glioblastoma multiforme; Multi decorated; Nucleoside analogues
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Year: 2016 PMID： 26994842 DOI： 10.1016/j.ejmech.2016.03.010
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514