| Literature DB >> 26994586 |
Daniel Wüthrich1, Céline L Boujon2, Laura Truchet2, Senija Selimovic-Hamza3, Anna Oevermann2, Ilias G Bouzalas2, Rémy Bruggmann4, Torsten Seuberlich5.
Abstract
Non-suppurative encephalitis is one of the most frequent pathological diagnosis in cattle with neurological disease, but there is a gap in the knowledge on disease-associated pathogens. In order to identify viruses that are associated with non-suppurative encephalitis in cattle, we used a viral metagenomics approach on a sample set of 16 neurologically-diseased cows. We detected six virus candidates: parainfluenza virus 5 (PIV-5), bovine astrovirus CH13/NeuroS1 (BoAstV-CH13/NeuroS1), bovine polyomavirus 2 (BPyV-2 SF), ovine herpesvirus 2 (OvHV-2), bovine herpesvirus 6 (BHV-6) and a novel bovine betaretrovirus termed BoRV-CH15. In a case-control study using PCR, BoAstV-CH13 (p=0.046), BoPV-2 SF (p=0.005) and BoHV-6 (p=4.3E-05) were statistically associated with the disease. These data expand our knowledge on encephalitis-associated pathogens in cattle and point to the value of NGS in resolving complex infection scenarios in a clinical disease setting.Entities:
Keywords: Astrovirus; Cattle; Encephalitis; Herpesvirus; Metagenomics; Neurological disease; Parainfluenza virus; Polyomavirus; Retrovirus
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Year: 2016 PMID： 26994586 DOI： 10.1016/j.virol.2016.03.009
Source DB: PubMed Journal: Virology ISSN： 0042-6822 Impact factor: 3.616