Seock Hwan Choi1, So Young Chun2, Tae-Hwan Kim1, Tae Gyun Kwon3. 1. Department of Urology, School of Medicine, Kyungpook National University, Daegu, Korea. 2. Joint Institute for Regenerative Medicine, Kyungpook National University Hospital, Daegu, Korea. 3. Department of Urology, School of Medicine, Kyungpook National University, Daegu, Korea. Electronic address: tgkwon@knu.ac.kr.
Abstract
OBJECTIVE: To assess the association and prognostic value of adipokines (adipocyte-secreted peptide hormones) in renal cell carcinoma (RCC). MATERIALS AND METHODS: Plasma samples from 54 RCC patients and 25 age-matched healthy controls were analyzed for levels of adipokines (adiponectin, leptin, retinol-binding protein 4 [RBP4], and nicotinamide phosphoribosyltransferase [NAMPT]). Baseline characteristics and adipokine levels were compared between patients and controls. The effect of adipokine levels on RCC severity was also investigated. RESULTS: Medians (patients/controls) were body mass index: 24.6/23.5kg/m(2), serum glucose: 111/93mg/dl, and high-density lipoprotein: 43/53mg/dl, and significantly differed between the 2 groups. Median levels (patients/controls) of adipokines were adiponectin: 4.36/8.84ug/ml, leptin: 2.91/2.92ng/ml, RBP4: 30.27/16.17ug/ml and NAMPT: 2.26/2.06ng/ml; adiponectin, RBP4 and NAMPT (but not leptin) were independently associated with RCC in logistic regression models, and only serum NAMPT was significantly associated with RCC severity (T stage). CONCLUSIONS: Lower plasma levels of adiponectin, and higher levels of RBP4 and NAMPT, are strongly correlated with RCC, indicating that these adipokines could be used as biomarkers for RCC.
OBJECTIVE: To assess the association and prognostic value of adipokines (adipocyte-secreted peptide hormones) in renal cell carcinoma (RCC). MATERIALS AND METHODS: Plasma samples from 54 RCCpatients and 25 age-matched healthy controls were analyzed for levels of adipokines (adiponectin, leptin, retinol-binding protein 4 [RBP4], and nicotinamide phosphoribosyltransferase [NAMPT]). Baseline characteristics and adipokine levels were compared between patients and controls. The effect of adipokine levels on RCC severity was also investigated. RESULTS: Medians (patients/controls) were body mass index: 24.6/23.5kg/m(2), serum glucose: 111/93mg/dl, and high-density lipoprotein: 43/53mg/dl, and significantly differed between the 2 groups. Median levels (patients/controls) of adipokines were adiponectin: 4.36/8.84ug/ml, leptin: 2.91/2.92ng/ml, RBP4: 30.27/16.17ug/ml and NAMPT: 2.26/2.06ng/ml; adiponectin, RBP4 and NAMPT (but not leptin) were independently associated with RCC in logistic regression models, and only serum NAMPT was significantly associated with RCC severity (T stage). CONCLUSIONS: Lower plasma levels of adiponectin, and higher levels of RBP4 and NAMPT, are strongly correlated with RCC, indicating that these adipokines could be used as biomarkers for RCC.
Authors: Sze Kiat Tan; Iqbal Mahmud; Flavia Fontanesi; Michelle Puchowicz; Chase K A Neumann; Anthony J Griswold; Rutulkumar Patel; Marco Dispagna; Hamzah H Ahmed; Mark L Gonzalgo; J Mark Brown; Timothy J Garrett; Scott M Welford Journal: Cancer Discov Date: 2021-03-23 Impact factor: 39.397