Evan Michael Shannon1, Ian T MacQueen2,3, Jeffrey M Miller4,5, Melinda Maggard-Gibbons6,7. 1. Department of Medicine, Brigham and Women's Hospital, 75 Francis St, Boston, MA, 02115, USA. 2. Department of Surgery, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA, 90095, USA. imacqueen@mednet.ucla.edu. 3. Department of Surgery, David Geffen School of Medicine at UCLA, 10833 LeConte Avenue, 72-215 Center for the Health Sciences, Box 956901, Los Angeles, CA, 90095-6901, USA. imacqueen@mednet.ucla.edu. 4. Division of Hematology and Oncology, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA, 90095, USA. 5. Division of Hematology and Oncology, Olive View-UCLA Medical Center, 14445 Olive View Drive, Sylmar, CA, 91342, USA. 6. Department of Surgery, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA, 90095, USA. 7. Department of Surgery, Olive View-UCLA Medical Center, 14445 Olive View Drive, Sylmar, CA, 91342, USA.
Abstract
INTRODUCTION: Primary gastrointestinal non-Hodgkin lymphomas (PGINHL) are a heterogeneous group of rare GI malignancies with limited data to guide management. This study describes management of PGINHL in a population-based registry and aims to determine the association between receipt of surgery and long-term survival. METHODS: All adults diagnosed with PGINHL over 27 years in the Surveillance, Epidemiology, and End Results were identified (excluding mucosa-associated lymphoid tissue lymphomas). Demographic and clinical characteristics were assessed. Survival was compared using the log-rank method. Cox hazard modeling was used to determine independent prognostic factors. RESULTS: We identified 16,129 patients. The majority were of gastric origin and had diffuse large B cell histology. Surgery was performed in 46.9 % of patients, not recommended in 41.8 % and recommended but not performed in 10.1 %. Overall 1-year and 5-year survival rates were 65.6 and 35.6 %, respectively. Patients undergoing surgery had a 5-year survival of 43.6 % compared to 34.8 % for whom surgery was recommended but not performed (p < .0001), (receipt of chemotherapy not available). Female gender, gastric location, follicular or mantle cell histology, and radiation therapy were associated with improved survival. CONCLUSIONS: Nearly 50 % of PGINHL patients underwent surgery. Surgery was not associated with improved survival. More prospective, case-matched studies are needed to guide management.
INTRODUCTION:Primary gastrointestinal non-Hodgkin lymphomas (PGINHL) are a heterogeneous group of rare GI malignancies with limited data to guide management. This study describes management of PGINHL in a population-based registry and aims to determine the association between receipt of surgery and long-term survival. METHODS: All adults diagnosed with PGINHL over 27 years in the Surveillance, Epidemiology, and End Results were identified (excluding mucosa-associated lymphoid tissue lymphomas). Demographic and clinical characteristics were assessed. Survival was compared using the log-rank method. Cox hazard modeling was used to determine independent prognostic factors. RESULTS: We identified 16,129 patients. The majority were of gastric origin and had diffuse large B cell histology. Surgery was performed in 46.9 % of patients, not recommended in 41.8 % and recommended but not performed in 10.1 %. Overall 1-year and 5-year survival rates were 65.6 and 35.6 %, respectively. Patients undergoing surgery had a 5-year survival of 43.6 % compared to 34.8 % for whom surgery was recommended but not performed (p < .0001), (receipt of chemotherapy not available). Female gender, gastric location, follicular or mantle cell histology, and radiation therapy were associated with improved survival. CONCLUSIONS: Nearly 50 % of PGINHL patients underwent surgery. Surgery was not associated with improved survival. More prospective, case-matched studies are needed to guide management.
Authors: N A Willich; G Reinartz; E J Horst; G Delker; B Reers; W Hiddemann; M Tiemann; R Parwaresch; B Grothaus-Pinke; J Kocik; P Koch Journal: Int J Radiat Oncol Biol Phys Date: 2000-03-01 Impact factor: 7.038
Authors: Jeeyun Lee; Won Seog Kim; Kihyun Kim; Young Hyeh Ko; Jae Jun Kim; Young Ho Kim; Ho Kyung Chun; Woo Yong Lee; Joon Oh Park; Chul Won Jung; Young-Hyuck Im; Mark H Lee; Won Ki Kang; Keunchil Park Journal: Leuk Lymphoma Date: 2004-02
Authors: J Hermans; A D Krol; K van Groningen; P M Kluin; J C Kluin-Nelemans; M H Kramer; E M Noordijk; F Ong; P W Wijermans Journal: Blood Date: 1995-08-15 Impact factor: 22.113
Authors: Sebastião D de Morais; Bruno M Mikhael; Stephanie I A Németh; Isabella M L Paulo; Érico O H de Barros; Olímpia A T Lima Journal: J Surg Case Rep Date: 2018-06-11