| Literature DB >> 26991945 |
Robert C Rennert1, Achal S Achrol2, Michael Januszyk1,3, Suzana A Kahn2, Tiffany T Liu3, Yi Liu3, Debashis Sahoo3, Melanie Rodrigues1, Zeshaan N Maan1, Victor W Wong1, Samuel H Cheshier2, Steven D Chang2, Gary K Steinberg2, Griffith R Harsh2, Geoffrey C Gurtner1.
Abstract
Brain tumor-initiating cells (BTICs) are self-renewing multipotent cells critical for tumor maintenance and growth. Using single-cell microfluidic profiling, we identified multiple subpopulations of BTICs coexisting in human glioblastoma, characterized by distinct surface marker expression and single-cell molecular profiles relating to divergent bulk tissue molecular subtypes. These data suggest BTIC subpopulation heterogeneity as an underlying source of intra-tumoral bulk tissue molecular heterogeneity, and will support future studies into BTIC subpopulation-specific therapies. Stem Cells 2016;34:1702-1707.Entities:
Keywords: Brain tumor initiating cells; Glioblastoma; Microfluidics; Molecular heterogeneity
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Year: 2016 PMID： 26991945 DOI： 10.1002/stem.2359
Source DB: PubMed Journal: Stem Cells ISSN： 1066-5099 Impact factor: 6.277