Literature DB >> 26990822

Brief Report: Apparent Antiretroviral Overadherence by Pill Count is Associated With HIV Treatment Failure in Adolescents.

Harriet Okatch1,2,3, Kaylin Beiter1, Jessica Eby1, Jennifer Chapman1, Tafireyi Marukutira4, Ontibile Tshume4, Mogomotsi Matshaba4,5, Gabriel M Anabwani4,5, Robert Gross6, Elizabeth Lowenthal1,7.   

Abstract

Pill counts with calculated adherence percentages are used in many settings to monitor adherence, but can be undermined by patients discarding pills to hide nonadherence. Pill counts suggesting that >100% of prescribed doses were taken can signal "pill dumping." We defined "overadherence" among a cohort of 300 HIV-infected adolescents as having greater than one-third of pill counts with >100% adherence during a year of follow-up. Apparent overadherence was more common in those with virologic failure than in those with suppressed viral loads (33% vs 13%, χ(2) P = 0.001). Pill count adherence repeatedly >100% may identify HIV-infected adolescents at increased risk of treatment failure.

Entities:  

Mesh：

Substances：

Year:  2016        PMID： 26990822      PMCID： PMC4942380          DOI： 10.1097/QAI.0000000000000994

Source DB:  PubMed          Journal:  J Acquir Immune Defic Syndr        ISSN： 1525-4135            Impact factor:   3.731


  13 in total

1.  Just say "I don't": lack of concordance between teen report and biological measures of drug use.

Authors:  Virginia Delaney-Black; Lisa M Chiodo; John H Hannigan; Mark K Greenwald; James Janisse; Grace Patterson; Marilyn A Huestis; Joel Ager; Robert J Sokol
Journal:  Pediatrics       Date:  2010-10-25       Impact factor: 7.124

2.  Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support.

Authors:  Paul A Harris; Robert Taylor; Robert Thielke; Jonathon Payne; Nathaniel Gonzalez; Jose G Conde
Journal:  J Biomed Inform       Date:  2008-09-30       Impact factor: 6.317

Review 3.  Adherence to medical recommendations and transition to adult services in pediatric transplant recipients.

Authors:  Eyal Shemesh; Rachel A Annunziato; Ronen Arnon; Tamir Miloh; Nanda Kerkar
Journal:  Curr Opin Organ Transplant       Date:  2010-06       Impact factor: 2.640

Review 4.  Adherence challenges in the management of type 1 diabetes in adolescents: prevention and intervention.

Authors:  Joshua S Borus; Lori Laffel
Journal:  Curr Opin Pediatr       Date:  2010-08       Impact factor: 2.856

Review 5.  Perinatally acquired HIV infection in adolescents from sub-Saharan Africa: a review of emerging challenges.

Authors:  Elizabeth D Lowenthal; Sabrina Bakeera-Kitaka; Tafireyi Marukutira; Jennifer Chapman; Kathryn Goldrath; Rashida A Ferrand
Journal:  Lancet Infect Dis       Date:  2014-01-07       Impact factor: 25.071

6.  How often is medication taken as prescribed? A novel assessment technique.

Authors:  J A Cramer; R H Mattson; M L Prevey; R D Scheyer; V L Ouellette
Journal:  JAMA       Date:  1989-06-09       Impact factor: 56.272

Review 7.  Microelectronic systems for monitoring and enhancing patient compliance with medication regimens.

Authors:  J A Cramer
Journal:  Drugs       Date:  1995-03       Impact factor: 9.546

Review 8.  Factors associated with adherence to antiretroviral therapy among adolescents living with HIV/AIDS in low- and middle-income countries: a systematic review.

Authors:  Carly Hudelson; Lucie Cluver
Journal:  AIDS Care       Date:  2015-02-23

9.  Evaluating adherence to highly active antiretroviral therapy with use of pill counts and viral load measurement in the drug resources enhancement against AIDS and malnutrition program in Mozambique.

Authors:  Massimo Magnano San Lio; Riccardo Carbini; Paola Germano; Giovanni Guidotti; Sandro Mancinelli; Noorjehan Abdul Magid; Pasquale Narciso; Leonardo Palombi; Elsa Renzi; Ines Zimba; Maria Cristina Marazzi
Journal:  Clin Infect Dis       Date:  2008-05-15       Impact factor: 9.079

10.  The use of pill counts as a facilitator of adherence with antiretroviral therapy in resource limited settings.

Authors:  Loice Achieng; Helen Musangi; Katherine Billingsley; Sharon Onguit; Edwin Ombegoh; LeeAnn Bryant; Jonathan Mwiindi; Nathaniel Smith; Philip Keiser
Journal:  PLoS One       Date:  2013-12-05       Impact factor: 3.240
View more
  22 in total

Review 1.  The Value of Assessing Self-Reported and Biological Indicators of Outcomes in Evaluating HIV Programs.

Authors:  Rick S Zimmerman; Purnima Mehrotra; Tessa Madden; Rachel Paul
Journal:  Curr HIV/AIDS Rep       Date:  2021-05-16       Impact factor: 5.071

Review 2.  Deception in clinical trials and its impact on recruitment and adherence of study participants.

Authors:  Chuen Peng Lee; Tyson Holmes; Eric Neri; Clete A Kushida
Journal:  Contemp Clin Trials       Date:  2018-08-21       Impact factor: 2.226

3.  Predictive Value of Tenofovir Diphosphate in Dried Blood Spots for Future Viremia in Persons Living With HIV.

Authors:  Mary Morrow; Samantha MaWhinney; Ryan P Coyle; Stacey S Coleman; Edward M Gardner; Jia-Hua Zheng; Lucas Ellison; Lane R Bushman; Jennifer J Kiser; Peter L Anderson; Jose R Castillo-Mancilla
Journal:  J Infect Dis       Date:  2019-07-19       Impact factor: 5.226

Review 4.  Approaches to Objectively Measure Antiretroviral Medication Adherence and Drive Adherence Interventions.

Authors:  Matthew A Spinelli; Jessica E Haberer; Peter R Chai; Jose Castillo-Mancilla; Peter L Anderson; Monica Gandhi
Journal:  Curr HIV/AIDS Rep       Date:  2020-08       Impact factor: 5.071

5.  High Medication Possession Ratios Associated With Greater Risk of Virologic Failure Among Youth Compared With Adults in a Nigerian Cohort.

Authors:  Aimalohi A Ahonkhai; Bolanle Banigbe; Juliet Adeola; Ingrid V Bassett; Ifeoma Idigbe; Prosper Okonkwo; Kenneth A Freedberg; Susan Regan; Elena Losina
Journal:  J Acquir Immune Defic Syndr       Date:  2018-07-01       Impact factor: 3.731

6.  Distinctive barriers to antiretroviral therapy adherence among non-adherent adolescents living with HIV in Botswana.

Authors:  Elizabeth Yang; Seipone Mphele; Neo Moshashane; Boineelo Bula; Jennifer Chapman; Harriet Okatch; Ed Pettitt; Ontibile Tshume; Tafireyi Marukutira; Gabriel Anabwani; Elizabeth Lowenthal
Journal:  AIDS Care       Date:  2017-06-23

7.  Virological and Immunological Antiretroviral Treatment Failure and Predictors Among HIV Positive Adult and Adolescent Clients in Southeast Ethiopia.

Authors:  Ayele Mamo; Tesfaye Assefa; Wegene Negash; Yohannes Takelign; Biniyam Sahiledinigl; Zinash Teferu; Mesud Mohammed; Damtew Solomon; Habtamu Gezahegn; Kebebe Bekele; Demsu Zenbaba; Alelign Tasew; Anwar Tahir; Fikereab Desta; Tadele Regassa; Abule Takele; Zegeye Regassa; Daniel Atilaw
Journal:  HIV AIDS (Auckl)       Date:  2022-02-26

Review 8.  Adherence Measurements in HIV: New Advancements in Pharmacologic Methods and Real-Time Monitoring.

Authors:  Jose R Castillo-Mancilla; Jessica E Haberer
Journal:  Curr HIV/AIDS Rep       Date:  2018-02       Impact factor: 5.071

9.  Feasibility and Acceptability of Real-Time Antiretroviral Adherence Monitoring among Depressed Women Living with HIV in the Deep South of the US.

Authors:  Kristi Lynn Stringer; Andres Azuero; Corilyn Ott; Christina Psaros; Christina H Jagielski; Steven A Safren; Jessica E Haberer; Mirjam-Colette Kempf
Journal:  AIDS Behav       Date:  2019-05

10.  Emtricitabine triphosphate in dried blood spots is a predictor of viral suppression in HIV infection and reflects short-term adherence to antiretroviral therapy.

Authors:  Katherine Frasca; Mary Morrow; Ryan P Coyle; Stacey S Coleman; Lucas Ellison; Lane R Bushman; Jennifer J Kiser; Jia-Hua Zheng; Samantha Mawhinney; Peter L Anderson; Jose Castillo-Mancilla
Journal:  J Antimicrob Chemother       Date:  2019-05-01       Impact factor: 5.790
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.