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Literature DB >> 26990528

Histone turnover and chromatin accessibility: Critical mediators of neurological development, plasticity, and disease.

Abstract

In postmitotic neurons, nucleosomal turnover was long considered to be a static process that is inconsequential to transcription. However, our recent studies in human and rodent brain indicate that replication-independent (RI) nucleosomal turnover, which requires the histone variant H3.3, is dynamic throughout life and is necessary for activity-dependent gene expression, synaptic connectivity, and cognition. H3.3 turnover also facilitates cellular lineage specification and plays a role in suppressing the expression of heterochromatic repetitive elements, including mutagenic transposable sequences, in mouse embryonic stem cells. In this essay, we review mechanisms and functions for RI nucleosomal turnover in brain and present the hypothesis that defects in histone dynamics may represent a common mechanism underlying neurological aging and disease.

Entities: Chemical

Keywords: H3.3; aging; histone variant; neurological disease; nucleosomal turnover; replication-independent

Mesh：

Substances：

Year: 2016 PMID： 26990528 PMCID： PMC4968875 DOI： 10.1002/bies.201500171

Source DB: PubMed Journal: Bioessays ISSN： 0265-9247 Impact factor: 4.345

114 in total

1. The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodies.

Authors: Yutong Xue; Richard Gibbons; Zhijiang Yan; Dafeng Yang; Tarra L McDowell; Salvatore Sechi; Jun Qin; Sharleen Zhou; Doug Higgs; Weidong Wang
Journal: Proc Natl Acad Sci U S A Date: 2003-09-02 Impact factor: 11.205

2. The atomic structure of the nucleosome core particle.

Authors: K Luger; A Mäder; D F Sargent; T J Richmond
Journal: J Biomol Struct Dyn Date: 2000

3. Genome-scale profiling of histone H3.3 replacement patterns.

Authors: Yoshiko Mito; Jorja G Henikoff; Steven Henikoff
Journal: Nat Genet Date: 2005-09-11 Impact factor: 38.330

4. Regulation of nucleosome landscape and transcription factor targeting at tissue-specific enhancers by BRG1.

Authors: Gangqing Hu; Dustin E Schones; Kairong Cui; River Ybarra; Daniel Northrup; Qingsong Tang; Luca Gattinoni; Nicholas P Restifo; Suming Huang; Keji Zhao
Journal: Genome Res Date: 2011-07-27 Impact factor: 9.043

5. Nucleosomes are context-specific, H2A.Z-modulated barriers to RNA polymerase.

Authors: Christopher M Weber; Srinivas Ramachandran; Steven Henikoff
Journal: Mol Cell Date: 2014-03-06 Impact factor: 17.970

6. Brain regional differences in the expansion of a CAG repeat in the spinocerebellar ataxias: dentatorubral-pallidoluysian atrophy, Machado-Joseph disease, and spinocerebellar ataxia type 1.

Authors: H Hashida; J Goto; H Kurisaki; H Mizusawa; I Kanazawa
Journal: Ann Neurol Date: 1997-04 Impact factor: 10.422

7. Histone H2A.Z subunit exchange controls consolidation of recent and remote memory.

Authors: Iva B Zovkic; Brynna S Paulukaitis; Jeremy J Day; Deepa M Etikala; J David Sweatt
Journal: Nature Date: 2014-09-14 Impact factor: 49.962

Review 8. Role of nucleosome remodeling in neurodevelopmental and intellectual disability disorders.

Authors: Alberto J López; Marcelo A Wood
Journal: Front Behav Neurosci Date: 2015-04-23 Impact factor: 3.558

9. Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells.

Authors: Simon J Elsässer; Laura A Banaszynski; Kyung-Min Noh; Nichole Diaz; C David Allis
Journal: Nature Date: 2015-05-04 Impact factor: 49.962

10. Analysis of neonatal brain lacking ATRX or MeCP2 reveals changes in nucleosome density, CTCF binding and chromatin looping.

Authors: Kristin D Kernohan; Douglas Vernimmen; Gregory B Gloor; Nathalie G Bérubé
Journal: Nucleic Acids Res Date: 2014-07-02 Impact factor: 16.971

10 in total

1. Postmitotic accumulation of histone variant H3.3 in new cortical neurons establishes neuronal chromatin, transcriptome, and identity.

Authors: Owen H Funk; Yaman Qalieh; Daniel Z Doyle; Mandy M Lam; Kenneth Y Kwan
Journal: Proc Natl Acad Sci U S A Date: 2022-08-05 Impact factor: 12.779

2. Replication-Independent Histone Variant H3.3 Controls Animal Lifespan through the Regulation of Pro-longevity Transcriptional Programs.

Authors: Antonia Piazzesi; Dražen Papić; Fabio Bertan; Paolo Salomoni; Pierluigi Nicotera; Daniele Bano
Journal: Cell Rep Date: 2016-10-18 Impact factor: 9.423

Review 9. Endogenous Retroviruses (ERVs): Does RLR (RIG-I-Like Receptors)-MAVS Pathway Directly Control Senescence and Aging as a Consequence of ERV De-Repression?

Authors: Eros Di Giorgio; Luigi E Xodo
Journal: Front Immunol Date: 2022-06-09 Impact factor: 8.786

10. Turnover of histones and histone variants in postnatal rat brain: effects of alcohol exposure.

Authors: Nadia Rachdaoui; Ling Li; Belinda Willard; Takhar Kasumov; Stephen Previs; Dipak Sarkar
Journal: Clin Epigenetics Date: 2017-10-23 Impact factor: 6.551