Eyal Kalanthroff1,2, Tobias Teichert3, Michael G Wheaton1,2,4, Marcia B Kimeldorf2, Omer Linkovski5, Susanne E Ahmari3, Abby J Fyer1,2, Franklin R Schneier1,2, Gideon E Anholt5, H Blair Simpson1,2. 1. Department of Psychiatry, Columbia University Medical Center, New York, New York. 2. Division of Clinical Therapeutics, New York State Psychiatric Institute, New York, New York. 3. Department of Psychiatry and the Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania. 4. Ferkauf Graduate School, Yeshiva University, New York, New York. 5. Department of Psychology, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Abstract
BACKGROUND: Numerous studies have investigated response inhibition (RI) in obsessive-compulsive disorder (OCD), with many reporting that OCD patients demonstrate deficits in RI as compared to controls. However, reported effect sizes tend to be modest and results have been inconsistent, with some studies finding intact RI in OCD. To date, no study has examined the effect of medications on RI in OCD patients. METHODS: We analyzed results from a stop-signal task to probe RI in 65 OCD patients (32 of whom were medicated) and 58 healthy controls (HCs). RESULTS: There was no statistically significant difference in stop-signal reaction time between the OCD group and the HC group, or between the medicated and unmedicated OCD patients. However, variability was significantly greater in the medicated OCD group compared to the unmedicated group. CONCLUSIONS: These results indicate that some samples of OCD patients do not have deficits in RI, making it unlikely that deficient RI underlies repetitive behaviors in all OCD patients. Future research is needed to fully elucidate the impact of medication use on stop-signal performance. Implications for future research on the cognitive processes underlying repetitive thoughts and behaviors are discussed.
BACKGROUND: Numerous studies have investigated response inhibition (RI) in obsessive-compulsive disorder (OCD), with many reporting that OCDpatients demonstrate deficits in RI as compared to controls. However, reported effect sizes tend to be modest and results have been inconsistent, with some studies finding intact RI in OCD. To date, no study has examined the effect of medications on RI in OCDpatients. METHODS: We analyzed results from a stop-signal task to probe RI in 65 OCDpatients (32 of whom were medicated) and 58 healthy controls (HCs). RESULTS: There was no statistically significant difference in stop-signal reaction time between the OCD group and the HC group, or between the medicated and unmedicated OCDpatients. However, variability was significantly greater in the medicated OCD group compared to the unmedicated group. CONCLUSIONS: These results indicate that some samples of OCDpatients do not have deficits in RI, making it unlikely that deficient RI underlies repetitive behaviors in all OCDpatients. Future research is needed to fully elucidate the impact of medication use on stop-signal performance. Implications for future research on the cognitive processes underlying repetitive thoughts and behaviors are discussed.
Authors: Stella J de Wit; Froukje E de Vries; Ysbrand D van der Werf; Danielle C Cath; Dirk J Heslenfeld; Eveline M Veltman; Anton J L M van Balkom; Dick J Veltman; Odile A van den Heuvel Journal: Am J Psychiatry Date: 2012-10 Impact factor: 18.112
Authors: W K Goodman; L H Price; S A Rasmussen; C Mazure; R L Fleischmann; C L Hill; G R Heninger; D S Charney Journal: Arch Gen Psychiatry Date: 1989-11
Authors: Lara Menzies; Sophie Achard; Samuel R Chamberlain; Naomi Fineberg; Chi-Hua Chen; Natalia del Campo; Barbara J Sahakian; Trevor W Robbins; Ed Bullmore Journal: Brain Date: 2007-09-13 Impact factor: 13.501
Authors: Claire M Gillan; Martina Papmeyer; Sharon Morein-Zamir; Barbara J Sahakian; Naomi A Fineberg; Trevor W Robbins; Sanne de Wit Journal: Am J Psychiatry Date: 2011-05-15 Impact factor: 18.112
Authors: Elizabeth Shephard; Emily R Stern; Odile A van den Heuvel; Daniel L C Costa; Marcelo C Batistuzzo; Priscilla B G Godoy; Antonio C Lopes; Andre R Brunoni; Marcelo Q Hoexter; Roseli G Shavitt; Y C Janardhan Reddy; Christine Lochner; Dan J Stein; H Blair Simpson; Euripedes C Miguel Journal: Mol Psychiatry Date: 2021-01-07 Impact factor: 15.992
Authors: A Kibleur; G Gras-Combe; D Benis; J Bastin; T Bougerol; S Chabardès; M Polosan; O David Journal: Transl Psychiatry Date: 2016-10-18 Impact factor: 6.222