Literature DB >> 26989766

Novel impact of EWI-2, CD9, and CD81 on TGF-β signaling in melanoma.

Hong-Xing Wang1, Martin E Hemler1.   

Abstract

Cell surface transmembrane protein IGFS8 (herein called EWI-2) negatively regulates melanoma TGF-β signaling and is well positioned to control the transition in TGF-β signaling from cytostatic (in early melanoma stages) to pro-invasion/metastasis (in later stages). EWI-2 functions by sequestering the tetraspanin proteins CD9 and CD81, thereby making them unavailable to support the association of TGFβ receptor 1 with TGFβ receptor 2.

Entities:  

Keywords:  CD81; CD9; EWI-2/IGSF8; TGF-β1; melanoma; tetraspanins

Year:  2015        PMID： 26989766      PMCID： PMC4792032          DOI： 10.1080/23723556.2015.1030536

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  EWI-2 is a new component of the tetraspanin web in hepatocytes and lymphoid cells.

Authors:  Stéphanie Charrin; François Le Naour; Valérie Labas; Martine Billard; Jean-Pierre Le Caer; Jean-François Emile; Marie-Anne Petit; Claude Boucheix; Eric Rubinstein
Journal:  Biochem J       Date:  2003-07-15       Impact factor: 3.857

2.  A gene expression database for the molecular pharmacology of cancer.

Authors:  U Scherf; D T Ross; M Waltham; L H Smith; J K Lee; L Tanabe; K W Kohn; W C Reinhold; T G Myers; D T Andrews; D A Scudiero; M B Eisen; E A Sausville; Y Pommier; D Botstein; P O Brown; J N Weinstein
Journal:  Nat Genet       Date:  2000-03       Impact factor: 38.330

3.  EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily.

Authors:  C S Stipp; T V Kolesnikova; M E Hemler
Journal:  J Biol Chem       Date:  2001-08-14       Impact factor: 5.157

4.  EWI-2 negatively regulates TGF-β signaling leading to altered melanoma growth and metastasis.

Authors:  Hong-Xing Wang; Chandan Sharma; Konstantin Knoblich; Scott R Granter; Martin E Hemler
Journal:  Cell Res       Date:  2015-02-06       Impact factor: 25.617

Review 5.  Roles of TGFbeta in metastasis.

Authors:  David Padua; Joan Massagué
Journal:  Cell Res       Date:  2009-01       Impact factor: 25.617

Review 6.  Targeting the TGFβ signalling pathway in disease.

Authors:  Rosemary J Akhurst; Akiko Hata
Journal:  Nat Rev Drug Discov       Date:  2012-09-24       Impact factor: 84.694

Review 7.  TGF-β: duality of function between tumor prevention and carcinogenesis.

Authors:  Daniel R Principe; Jennifer A Doll; Jessica Bauer; Barbara Jung; Hidayatullah G Munshi; Laurent Bartholin; Boris Pasche; Chung Lee; Paul J Grippo
Journal:  J Natl Cancer Inst       Date:  2014-02       Impact factor: 13.506

8.  Profiling of the tetraspanin web of human colon cancer cells.

Authors:  François Le Naour; Magali André; Céline Greco; Martine Billard; Bernard Sordat; Jean-François Emile; François Lanza; Claude Boucheix; Eric Rubinstein
Journal:  Mol Cell Proteomics       Date:  2006-02-07       Impact factor: 5.911

9.  A novel cysteine cross-linking method reveals a direct association between claudin-1 and tetraspanin CD9.

Authors:  Oleg V Kovalenko; Xiuwei H Yang; Martin E Hemler
Journal:  Mol Cell Proteomics       Date:  2007-07-20       Impact factor: 5.911

10.  Insights into the Transforming Growth Factor-β Signaling Pathway in Cutaneous Melanoma.

Authors:  Carole Yolande Perrot; Delphine Javelaud; Alain Mauviel
Journal:  Ann Dermatol       Date:  2013-05       Impact factor: 1.444
  10 in total
  4 in total

1.  EWI2 promotes endolysosome-mediated turnover of growth factor receptors and integrins to suppress lung cancer.

Authors:  Jie Wang; Jonathan D Wren; Yingjun Ding; Junxiong Chen; Nikhil Mittal; Chao Xu; Xing Li; Cengxi Zeng; Meng Wang; Jing Shi; Yanhui H Zhang; Sangyoon J Han; Xin A Zhang
Journal:  Cancer Lett       Date:  2022-03-24       Impact factor: 9.756

2.  Proteomic Comparison of Malignant Human Germ Cell Tumor Cell Lines.

Authors:  Felix Bremmer; Hanibal Bohnenberger; Stefan Küffer; Thomas Oellerich; Hubert Serve; Henning Urlaub; Arne Strauss; Yasmine Maatoug; Carl Ludwig Behnes; Christoph Oing; Heinz Joachim Radzun; Philipp Ströbel; Stefan Balabanov; Friedemann Honecker
Journal:  Dis Markers       Date:  2019-09-03       Impact factor: 3.434

3.  EWI-2 controls nucleocytoplasmic shuttling of EGFR signaling molecules and miRNA sorting in exosomes to inhibit prostate cancer cell metastasis.

Authors:  Chenying Fu; Qing Zhang; Ani Wang; Songpeng Yang; Yangfu Jiang; Lin Bai; Quan Wei
Journal:  Mol Oncol       Date:  2021-03-27       Impact factor: 6.603

Review 4.  Antitumor Immunity Is Controlled by Tetraspanin Proteins.

Authors:  Fleur Schaper; Annemiek B van Spriel
Journal:  Front Immunol       Date:  2018-05-29       Impact factor: 7.561
  4 in total

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