Anna Materna-Kiryluk1, Barbara Więckowska2, Katarzyna Wiśniewska3, Małgorzata Czyżewska4, Urszula Godula-Stuglik5, Małgorzata Baumert6, Ryszard Margol7, Anna Latos-Bieleńska8. 1. Poznan University of Medical Sciences, Poznań, Poland (Department of Medical Genetics). akiryluk@ump.edu.pl. 2. Poznan University of Medical Sciences, Poznań, Poland (Department of Computer Science and Statistics). basia@ump.edu.pl. 3. Poznan University of Medical Sciences, Poznań, Poland (Department of Preventive Medicine). 4. Wroclaw Medical University, Wrocław, Poland (Department and Clinic of Neonatology). 5. Medical University of Silesia, Katowice, Poland (Department of Pediatrics in Zabrze). 6. Medical University of Silesia, Katowice, Poland (Department of Neonatology). 7. Poviat Hospital, Nysa, Poland (Neonatal Unit). 8. Poznan University of Medical Sciences, Poznań, Poland (Department of Medical Genetics).
Abstract
OBJECTIVES: The aims of this study were: to evaluate the prevalence of abdominal wall defects in the Polish population, to analyze temporal trends in the prevalence, to identify areas (clusters) of high risk of abdominal wall defects, and to characterize, with respect to epidemiology, children with abdominal wall defects and their mothers in the area defined as a cluster. MATERIAL AND METHODS: We used isolated congenital malformations (gastroschisis Q79.3 and omphalocele Q79.2 according to the International Statistical Classification of Diseases and Related Health Problems, 10th revision (ICD-10, the extended version)) data reported to the Polish Registry of Congenital Malformations (PRCM) over the years 1998- 2008 based on the population of 2 362 502 live births. We analyzed 11 administrative regions of Poland with complete epidemiologic data. RESULTS: Of 11 regions, 2 had a significantly higher standardized prevalence of isolated gastroschisis: Dolnośląskie (1.7/10 000 live births, p = 0.0052) and Śląskie (1.9/10 000 live births, p < 0.0001). Furthermore, within the region of Dolnośląskie, we defined a clear prevalence of the isolated gastroschisis cluster (p = 0.023). We comprehensively examined demographic and socio-economic risk factors for abdominal wall defects in this area, and we found that these factors failed to account for the cluster. CONCLUSIONS: We identified a distinct prevalence cluster for isolated gastroschisis, although a precise reason for the disease clustering in this region remains unknown. Cluster identification enables more focused research aimed at identification of specific factors with teratogenic effects. This work is available in Open Access model and licensed under a CC BY-NC 3.0 PL license.
OBJECTIVES: The aims of this study were: to evaluate the prevalence of abdominal wall defects in the Polish population, to analyze temporal trends in the prevalence, to identify areas (clusters) of high risk of abdominal wall defects, and to characterize, with respect to epidemiology, children with abdominal wall defects and their mothers in the area defined as a cluster. MATERIAL AND METHODS: We used isolated congenital malformations (gastroschisis Q79.3 and omphalocele Q79.2 according to the International Statistical Classification of Diseases and Related Health Problems, 10th revision (ICD-10, the extended version)) data reported to the Polish Registry of Congenital Malformations (PRCM) over the years 1998- 2008 based on the population of 2 362 502 live births. We analyzed 11 administrative regions of Poland with complete epidemiologic data. RESULTS: Of 11 regions, 2 had a significantly higher standardized prevalence of isolated gastroschisis: Dolnośląskie (1.7/10 000 live births, p = 0.0052) and Śląskie (1.9/10 000 live births, p < 0.0001). Furthermore, within the region of Dolnośląskie, we defined a clear prevalence of the isolated gastroschisis cluster (p = 0.023). We comprehensively examined demographic and socio-economic risk factors for abdominal wall defects in this area, and we found that these factors failed to account for the cluster. CONCLUSIONS: We identified a distinct prevalence cluster for isolated gastroschisis, although a precise reason for the disease clustering in this region remains unknown. Cluster identification enables more focused research aimed at identification of specific factors with teratogenic effects. This work is available in Open Access model and licensed under a CC BY-NC 3.0 PL license.
Authors: Victor M Salinas-Torres; Rafael A Salinas-Torres; Ricardo M Cerda-Flores; Laura E Martínez-de-Villarreal Journal: Pediatr Surg Int Date: 2018-01-15 Impact factor: 1.827
Authors: Elisabeth Pechriggl; Michael Blumer; R Shane Tubbs; Łukasz Olewnik; Marko Konschake; René Fortélny; Hannes Stofferin; Hanne Rose Honis; Sara Quinones; Eva Maranillo; José Sanudo Journal: Front Surg Date: 2022-07-07