| Literature DB >> 26988029 |
Sami El Deeb1, Hermann Wätzig1, Deia Abd El-Hady2,3, Cari Sänger-van de Griend4,5,6, Gerhard K E Scriba7.
Abstract
This review updates and follows-up a previous review by highlighting recent advancements regarding capillary electromigration methodologies and applications in pharmaceutical analysis. General approaches such as quality by design as well as sample injection methods and detection sensitivity are discussed. The separation and analysis of drug-related substances, chiral CE, and chiral CE-MS in addition to the determination of physicochemical constants are addressed. The advantages of applying affinity capillary electrophoresis in studying receptor-ligand interactions are highlighted. Finally, current aspects related to the analysis of biopharmaceuticals are reviewed. The present review covers the literature between January 2013 and December 2015.Keywords: Biopharmaceuticals; Capillary electrophoresis; Pharmaceutical analysis; Quantitation
Mesh：
Substances：
Year: 2016 PMID： 26988029 DOI： 10.1002/elps.201600058
Source DB: PubMed Journal: Electrophoresis ISSN： 0173-0835 Impact factor: 3.535