Michal Stein1, Jacqueline Komerska2, Miriam Prizade3, Bracha Sheinberg3, Diana Tasher4, Eli Somekh4. 1. Infectious Diseases Unit, Hilel Yaffe Medical Center, PO Box 169, Hadera, 38100 Israel. Electronic address: michal.stein@gmail.com. 2. Pediatric Infectious Diseases Unit, Wolfson Medical Center, Holon, Israel. 3. Maccabi Health Services, Israel. 4. Pediatric Infectious Diseases Unit, Wolfson Medical Center, Holon, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Abstract
OBJECTIVES: The objectives of this study were to characterize isolates of Staphylococcus aureus obtained from skin and soft tissue infections in the community in Israel and to document the sensitivity patterns for commonly used antimicrobial agents. METHODS: The susceptibilities of S. aureus isolates from skin and soft tissue infections in the community in Israel were reviewed to determine the appropriate empirical therapy for these infections. RESULTS: A total of 7221 isolates were collected during the period 2009-2012; 39% were from children (age 0-18 years). In children, S. aureus oxacillin resistance dropped from 8.4% to 3.8% (p=0.073). While inducible clindamycin resistance increased slightly from 20% to 25%, there was a prominent increase in constitutive clindamycin resistance from 0.1% to 26.8% (p=0.012). In adults, oxacillin resistance increased from 16% to 23% (p<0.001) and constitutive clindamycin resistance increased notably from 5% to 29% (p<0.001). These findings demonstrate a dramatic increase in clindamycin resistance among S. aureus isolates and suggest against the usage of clindamycin as empirical treatment for suspected S. aureus infections in Israel. CONCLUSIONS: Beta-lactam anti-staphylococcal agents may be given as empirical treatment for children, but should be considered according to risk factors for adults in Israel.
OBJECTIVES: The objectives of this study were to characterize isolates of Staphylococcus aureus obtained from skin and soft tissue infections in the community in Israel and to document the sensitivity patterns for commonly used antimicrobial agents. METHODS: The susceptibilities of S. aureus isolates from skin and soft tissue infections in the community in Israel were reviewed to determine the appropriate empirical therapy for these infections. RESULTS: A total of 7221 isolates were collected during the period 2009-2012; 39% were from children (age 0-18 years). In children, S. aureusoxacillin resistance dropped from 8.4% to 3.8% (p=0.073). While inducible clindamycin resistance increased slightly from 20% to 25%, there was a prominent increase in constitutive clindamycin resistance from 0.1% to 26.8% (p=0.012). In adults, oxacillin resistance increased from 16% to 23% (p<0.001) and constitutive clindamycin resistance increased notably from 5% to 29% (p<0.001). These findings demonstrate a dramatic increase in clindamycin resistance among S. aureus isolates and suggest against the usage of clindamycin as empirical treatment for suspected S. aureus infections in Israel. CONCLUSIONS:Beta-lactam anti-staphylococcal agents may be given as empirical treatment for children, but should be considered according to risk factors for adults in Israel.
Authors: Mieke Vermandere; Bert Aertgeerts; Thomas Agoritsas; Catherine Liu; Jako Burgers; Arnaud Merglen; Patrick Mbah Okwen; Lyubov Lytvyn; Shunjie Chua; Per O Vandvik; Gordon H Guyatt; Claudia Beltran-Arroyave; Valéry Lavergne; Reinhart Speeckaert; Finn E Steen; Victoria Arteaga; Rachelle Sender; Shelley McLeod; Xin Sun; Wen Wang; Reed A C Siemieniuk Journal: BMJ Date: 2018-02-06
Authors: Peng Gao; Yuanxin Wei; Rachel Evelyn Wan; Ka Wing Wong; Ho Ting Venice Iu; Sherlock Shing Chiu Tai; Yongli Li; Hin Cheung Bill Yam; Pradeep Halebeedu Prakash; Jonathan Hon Kwan Chen; Pak Leung Ho; Kwok Yung Yuen; Julian Davies; Richard Yi Tsun Kao Journal: Microbiol Spectr Date: 2022-06-27