Literature DB >> 26986633

Scaling-down antibody radiolabeling reactions with zirconium-89.

James C Knight1, Stephen J Paisey2, Adam M Dabkowski2, Cristina Marculescu1, Anwen S Williams3, Christopher Marshall2, Bart Cornelissen1.   

Abstract

The most widely cited procedures for radiolabeling antibodies with zirconium-89 for immuno-PET require multi-milligram amounts of antibody which can be cost-prohibitive, particularly during the research and development process. We therefore sought to develop a reliable (89)Zr-radiolabeling procedure that provides high radiochemical yields at the microgram scale.

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Year:  2016        PMID： 26986633     DOI： 10.1039/c5dt04774a

Source DB:  PubMed          Journal:  Dalton Trans        ISSN： 1477-9226            Impact factor:   4.390


  7 in total

1.  89Zr-Chloride Can Be Used for Immuno-PET Radiochemistry Without Loss of Antigen Reactivity In Vivo.

Authors:  Darpan N Pandya; Nikunj B Bhatt; Frankis Almaguel; Stephanie Rideout-Danner; Howard D Gage; Kiran Kumar Solingapuram Sai; Thaddeus J Wadas
Journal:  J Nucl Med       Date:  2018-11-15       Impact factor: 10.057

2.  A comprehensively revised strategy that improves the specific activity and long-term stability of clinically relevant 89Zr-immuno-PET agents.

Authors:  Nikunj B Bhatt; Darpan N Pandya; Stephanie Rideout-Danner; Howard D Gage; Frank C Marini; Thaddeus J Wadas
Journal:  Dalton Trans       Date:  2018-09-04       Impact factor: 4.390

3.  Dual-isotope imaging allows in vivo immunohistochemistry using radiolabelled antibodies in tumours.

Authors:  James C Knight; Michael J Mosley; Veerle Kersemans; Gemma M Dias; P Danny Allen; Sean Smart; Bart Cornelissen
Journal:  Nucl Med Biol       Date:  2019-02-05       Impact factor: 2.408

4.  Probing the limits of Q-tag bioconjugation of antibodies.

Authors:  Cristina Marculescu; Abirami Lakshminarayanan; Joseph Gault; James C Knight; Lisa K Folkes; Thomas Spink; Carol V Robinson; Katherine Vallis; Benjamin G Davis; Bart Cornelissen
Journal:  Chem Commun (Camb)       Date:  2019-09-19       Impact factor: 6.065

5.  Synthesis and In Vivo Evaluation of a Site-specifically Labeled Radioimmunoconjugate for Dual-Modal (PET/NIRF) Imaging of MT1-MMP in Sarcomas.

Authors:  Toni A Pringle; Corey D Chan; Saimir Luli; Helen J Blair; Kenneth S Rankin; James C Knight
Journal:  Bioconjug Chem       Date:  2022-07-22       Impact factor: 6.069

6.  A Systematic Evaluation of Antibody Modification and 89Zr-Radiolabeling for Optimized Immuno-PET.

Authors:  Sai Kiran Sharma; Jonathan M Glaser; Kimberly J Edwards; Elaheh Khozeimeh Sarbisheh; Akam K Salih; Jason S Lewis; Eric W Price
Journal:  Bioconjug Chem       Date:  2020-04-01       Impact factor: 6.069

7.  Biodistribution PET/CT Study of Hemoglobin-DFO-89Zr Complex in Healthy and Lung Tumor-Bearing Mice.

Authors:  Łukasz Kiraga; Gabriele Cerutti; Agata Braniewska; Damian Strzemecki; Zuzanna Sas; Alberto Boffi; Carmelinda Savino; Linda Celeste Montemiglio; Daniel Turnham; Gillian Seaton; Alessandra Bonamore; Richard Clarkson; Adam M Dabkowski; Stephen J Paisey; Bartłomiej Taciak; Paulina Kucharzewska; Tomasz P Rygiel; Magdalena Król
Journal:  Int J Mol Sci       Date:  2020-07-15       Impact factor: 5.923
  7 in total

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