Literature DB >> 26985808

Emerging nexus between RAB GTPases, autophagy and neurodegeneration.

Navodita Jain1, Subramaniam Ganesh1.   

Abstract

The RAB class of small GTPases includes the major regulators of intracellular communication, which are involved in vesicle generation through fusion and fission, and vesicular trafficking. RAB proteins also play an imperative role in neuronal maintenance and survival. Recent studies in the field of neurodegeneration have also highlighted the process of autophagy as being essential for neuronal maintenance. Here we review the emerging roles of RAB proteins in regulating macroautophagy and its impact in the context of neurodegenerative diseases.

Entities:  

Keywords:  GTPase; RAB proteins; autophagy; endocytosis; intracellular trafficking; neurodegeneration; neuronal maintenance; stress response

Mesh：

Substances：

Year:  2016        PMID： 26985808      PMCID： PMC4854548          DOI： 10.1080/15548627.2016.1147673

Source DB:  PubMed          Journal:  Autophagy        ISSN： 1554-8627            Impact factor:   16.016


  33 in total

1.  Dysfunctions in endosomal-lysosomal and autophagy pathways underlie neuropathology in a mouse model for Lafora disease.

Authors:  Rajat Puri; Toshimitsu Suzuki; Kazuhiro Yamakawa; Subramaniam Ganesh
Journal:  Hum Mol Genet       Date:  2011-09-30       Impact factor: 6.150

2.  Huntingtin differentially regulates the axonal transport of a sub-set of Rab-containing vesicles in vivo.

Authors:  Joseph A White; Eric Anderson; Katherine Zimmerman; Kan Hong Zheng; Roza Rouhani; Shermali Gunawardena
Journal:  Hum Mol Genet       Date:  2015-10-08       Impact factor: 6.150

3.  Intracellular accumulation of toxic turn amyloid-β is associated with endoplasmic reticulum stress in Alzheimer's disease.

Authors:  Naoko Soejima; Yasumasa Ohyagi; Norimichi Nakamura; Eri Himeno; Kyoko M Iinuma; Nobutaka Sakae; Ryo Yamasaki; Takeshi Tabira; Kazuma Murakami; Kazuhiro Irie; Noriaki Kinoshita; Frank M LaFerla; Yutaka Kiyohara; Toru Iwaki; Jun-ichi Kira
Journal:  Curr Alzheimer Res       Date:  2013-01       Impact factor: 3.498

4.  Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy.

Authors:  Koji Yamano; Adam I Fogel; Chunxin Wang; Alexander M van der Bliek; Richard J Youle
Journal:  Elife       Date:  2014-02-25       Impact factor: 8.140

5.  Rab11 facilitates cross-talk between autophagy and endosomal pathway through regulation of Hook localization.

Authors:  Zsuzsanna Szatmári; Viktor Kis; Mónika Lippai; Krisztina Hegedus; Tamás Faragó; Péter Lorincz; Tsubasa Tanaka; Gábor Juhász; Miklós Sass
Journal:  Mol Biol Cell       Date:  2013-12-19       Impact factor: 4.138

6.  Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex.

Authors:  Nicole C McKnight; Yun Zhong; Mitchell S Wold; Shiaoching Gong; Greg R Phillips; Zhixun Dou; Yanxiang Zhao; Nathaniel Heintz; Wei-Xing Zong; Zhenyu Yue
Journal:  PLoS Genet       Date:  2014-10-02       Impact factor: 5.917

7.  Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease.

Authors:  Brinda Ravikumar; Sara Imarisio; Sovan Sarkar; Cahir J O'Kane; David C Rubinsztein
Journal:  J Cell Sci       Date:  2008-04-22       Impact factor: 5.285

8.  Molecular basis of Charcot-Marie-Tooth type 2B disease.

Authors:  Cecilia Bucci; Maria De Luca
Journal:  Biochem Soc Trans       Date:  2012-12-01       Impact factor: 5.407

9.  Canine hereditary ataxia in old english sheepdogs and gordon setters is associated with a defect in the autophagy gene encoding RAB24.

Authors:  Caryline Agler; Dahlia M Nielsen; Ganokon Urkasemsin; Andrew Singleton; Noriko Tonomura; Snaevar Sigurdsson; Ruqi Tang; Keith Linder; Sampath Arepalli; Dena Hernandez; Kerstin Lindblad-Toh; Joyce van de Leemput; Alison Motsinger-Reif; Dennis P O'Brien; Jerold Bell; Tonya Harris; Steven Steinberg; Natasha J Olby
Journal:  PLoS Genet       Date:  2014-02-06       Impact factor: 5.917

10.  Rab11 modulates α-synuclein-mediated defects in synaptic transmission and behaviour.

Authors:  Carlo Breda; Marie L Nugent; Jasper G Estranero; Charalambos P Kyriacou; Tiago F Outeiro; Joern R Steinert; Flaviano Giorgini
Journal:  Hum Mol Genet       Date:  2014-10-09       Impact factor: 6.150
View more
  7 in total

Review 1.  Roles for RAB24 in autophagy and disease.

Authors:  Päivi Ylä-Anttila; Eeva-Liisa Eskelinen
Journal:  Small GTPases       Date:  2017-05-19

2.  RAB26-dependent autophagy protects adherens junctional integrity in acute lung injury.

Authors:  Weijie Dong; Binfeng He; Hang Qian; Qian Liu; Dong Wang; Jin Li; Zhenghua Wei; Zi Wang; Zhi Xu; Guangyu Wu; Guisheng Qian; Guansong Wang
Journal:  Autophagy       Date:  2018-07-26       Impact factor: 16.016

Review 3.  Small GTPases of the Rab and Arf Families: Key Regulators of Intracellular Trafficking in Neurodegeneration.

Authors:  Alazne Arrazola Sastre; Miriam Luque Montoro; Hadriano M Lacerda; Francisco Llavero; José L Zugaza
Journal:  Int J Mol Sci       Date:  2021-04-23       Impact factor: 5.923

Review 4.  C9orf72's Interaction with Rab GTPases-Modulation of Membrane Traffic and Autophagy.

Authors:  Bor L Tang
Journal:  Front Cell Neurosci       Date:  2016-10-07       Impact factor: 5.505

5.  Distinct Rab7-related Endosomal-Autophagic-Lysosomal Dysregulation Observed in Cortex and Hippocampus in APPswe/PSEN1dE9 Mouse Model of Alzheimer's Disease.

Authors:  Li Ba; Xiao-Hua Chen; Yan-Lin Chen; Qing Nie; Zhi-Jun Li; Feng-Fei Ding; Min Zhang
Journal:  Chin Med J (Engl)       Date:  2017-12-20       Impact factor: 2.628

Review 6.  Rab GTPases: The principal players in crafting the regulatory landscape of endosomal trafficking.

Authors:  Jing Zhang; Zongyan Jiang; Anbing Shi
Journal:  Comput Struct Biotechnol J       Date:  2022-08-11       Impact factor: 6.155

7.  Changes in endolysosomal organization define a pre-degenerative state in the crumbs mutant Drosophila retina.

Authors:  Rachel S Kraut; Elisabeth Knust
Journal:  PLoS One       Date:  2019-12-13       Impact factor: 3.240
  7 in total

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