Literature DB >> 26985309

Astemizole Derivatives as Fluorescent Probes for hERG Potassium Channel Imaging.

Beilei Wang1, Zhenzhen Liu1, Zhao Ma1, Minyong Li1, Lupei Du1.   

Abstract

The detection and imaging of hERG potassium channels in living cells can provide useful information for hERG-correlation studies. Herein, three small-molecule fluorescent probes, based on the potent hERG channel inhibitor astemizole, for the imaging of hERG channels in hERG-transfected HEK293 cells (hERG-HEK293) and human colorectal cancer cells (HT-29), are described. These probes are expected to be applied in the physiological and pathological studies of hERG channels.

Entities:  

Keywords:  astemizole; cell imaging; fluorescent probes; hERG potassium channel

Year:  2016        PMID： 26985309      PMCID： PMC4789673          DOI： 10.1021/acsmedchemlett.5b00360

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  26 in total

1.  A novel hypothesis for the binding mode of HERG channel blockers.

Authors:  Han Choe; Kwang Hoon Nah; Soo Nam Lee; Han Sam Lee; Hui Sun Lee; Su Hyun Jo; Chae Hun Leem; Yeon Jin Jang
Journal:  Biochem Biophys Res Commun       Date:  2006-03-31       Impact factor: 3.575

2.  The potent inhibitory effects of cisapride, a specific blocker for human ether-a-go-go-related gene (HERG) channel, on gastric cancer cells.

Authors:  Xiao-Dong Shao; Kai-Chun Wu; Zhi-Ming Hao; Liu Hong; Jing Zhang; Dai-Ming Fan
Journal:  Cancer Biol Ther       Date:  2005-03-20       Impact factor: 4.742

3.  A novel structure-based virtual screening model for the hERG channel blockers.

Authors:  Lupei Du; Minyong Li; Qidong You; Lin Xia
Journal:  Biochem Biophys Res Commun       Date:  2007-02-22       Impact factor: 3.575

4.  Functional up-regulation of HERG K+ channels in neoplastic hematopoietic cells.

Authors:  Garth A M Smith; Hing-Wo Tsui; Evan W Newell; Xinpo Jiang; Xiao-Ping Zhu; Florence W L Tsui; Lyanne C Schlichter
Journal:  J Biol Chem       Date:  2002-03-13       Impact factor: 5.157

5.  Development of the predictor HERG fluorescence polarization assay using a membrane protein enrichment approach.

Authors:  David R Piper; Steve R Duff; Hildegard C Eliason; W Jack Frazee; Elizabeth A Frey; Maya Fuerstenau-Sharp; Christine Jachec; Bryan D Marks; Brian A Pollok; Mohammed Saleh Shekhani; David V Thompson; Pam Whitney; Kurt W Vogel; Stephen D Hess
Journal:  Assay Drug Dev Technol       Date:  2008-04       Impact factor: 1.738

6.  herg1 gene and HERG1 protein are overexpressed in colorectal cancers and regulate cell invasion of tumor cells.

Authors:  Elena Lastraioli; Leonardo Guasti; Olivia Crociani; Simone Polvani; Giovanna Hofmann; Harry Witchel; Lapo Bencini; Massimo Calistri; Luca Messerini; Marco Scatizzi; Renato Moretti; Enzo Wanke; Massimo Olivotto; Gabriele Mugnai; Annarosa Arcangeli
Journal:  Cancer Res       Date:  2004-01-15       Impact factor: 12.701

Review 7.  hERG potassium channels and cardiac arrhythmia.

Authors:  Michael C Sanguinetti; Martin Tristani-Firouzi
Journal:  Nature       Date:  2006-03-23       Impact factor: 49.962

Review 8.  Current pharmacogenomic studies on hERG potassium channels.

Authors:  Fa-Zhong He; Howard L McLeod; Wei Zhang
Journal:  Trends Mol Med       Date:  2013-01-29       Impact factor: 11.951

9.  HERG potassium channels are more frequently expressed in human endometrial cancer as compared to non-cancerous endometrium.

Authors:  A Cherubini; G L Taddei; O Crociani; M Paglierani; A M Buccoliero; L Fontana; I Noci; P Borri; E Borrani; M Giachi; A Becchetti; B Rosati; E Wanke; M Olivotto; A Arcangeli
Journal:  Br J Cancer       Date:  2000-12       Impact factor: 7.640

10.  Fluorogenic probe for the human Ether-a-Go-Go-Related Gene potassium channel imaging.

Authors:  Zhenzhen Liu; Beilei Wang; Zhao Ma; Yubin Zhou; Lupei Du; Minyong Li
Journal:  Anal Chem       Date:  2015-02-12       Impact factor: 6.986
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  3 in total

1.  Astemizole-based turn-on fluorescent probes for imaging hERG potassium channel.

Authors:  Xiaomeng Zhang; Tingting Liu; Beilei Wang; Yuqi Gao; Pan Liu; Minyong Li; Lupei Du
Journal:  Medchemcomm       Date:  2019-02-26       Impact factor: 3.597

2.  3-D structural interactions and quantitative structural toxicity studies of tyrosine derivatives intended for safe potent inflammation treatment.

Authors:  Ayarivan Puratchikody; Dharmaraj Sriram; Appavoo Umamaheswari; Navabshan Irfan
Journal:  Chem Cent J       Date:  2016-04-30       Impact factor: 4.215

3.  NBD-Based Environment-Sensitive Fluorescent Probes for the Human Ether-a-Go-Go-Related Gene Potassium Channel.

Authors:  Qi Li; Lijuan Chai; Gaopan Dong; Xiaomeng Zhang; Lupei Du
Journal:  Front Mol Biosci       Date:  2021-05-14
  3 in total

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