Yunqi Zhu1, Ruili Du2, Yuankai Zhu1, Yehua Shen1, Kai Zhang1, Yao Chen1, Fahuan Song1, Shuang Wu1, Hong Zhang3, Mei Tian4. 1. Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China Zhejiang University Medical PET Center, Hangzhou, China Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China; and. 2. Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China Zhejiang University Medical PET Center, Hangzhou, China Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China; and meitian@zju.edu.cn. 3. Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China Zhejiang University Medical PET Center, Hangzhou, China Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China; and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, China. 4. Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China Zhejiang University Medical PET Center, Hangzhou, China Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China; and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, China meitian@zju.edu.cn.
Abstract
UNLABELLED: Posttraumatic stress disorder (PTSD) is an anxiety disorder that occurs after exposure to a traumatic event. This study aimed to investigate the neurobiologic changes before and after exposure-based therapy by PET in a rat model of PTSD. METHODS: Serial (18)F-FDG PET imaging studies were performed under the control (tone presentation), fear-conditioning, and extinction retrieval phases. Neuroactivity marker c-Fos protein was used for immunostaining. RESULTS: Increased glucose metabolism was observed in the bilateral amygdala after fear-conditioning (P < 0.001) and in the right posterior insular cortex under extinction retrieval (P < 0.001) compared with the control phase. Increased c-Fos expression in the posterior insular cortex under extinction retrieval was positively correlated to the glucose metabolism (P < 0.01). CONCLUSION: Our results indicated that the amygdala plays a key role in fear memory formation and, most importantly, the insular cortex is related to the retrieval of extinction memory. (18)F-FDG PET may provide a promising in vivo approach for evaluating exposure-based therapy of PTSD.
UNLABELLED: Posttraumatic stress disorder (PTSD) is an anxiety disorder that occurs after exposure to a traumatic event. This study aimed to investigate the neurobiologic changes before and after exposure-based therapy by PET in a rat model of PTSD. METHODS: Serial (18)F-FDG PET imaging studies were performed under the control (tone presentation), fear-conditioning, and extinction retrieval phases. Neuroactivity marker c-Fos protein was used for immunostaining. RESULTS: Increased glucose metabolism was observed in the bilateral amygdala after fear-conditioning (P < 0.001) and in the right posterior insular cortex under extinction retrieval (P < 0.001) compared with the control phase. Increased c-Fos expression in the posterior insular cortex under extinction retrieval was positively correlated to the glucose metabolism (P < 0.01). CONCLUSION: Our results indicated that the amygdala plays a key role in fear memory formation and, most importantly, the insular cortex is related to the retrieval of extinction memory. (18)F-FDG PET may provide a promising in vivo approach for evaluating exposure-based therapy of PTSD.
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