| Literature DB >> 26983737 |
Abstract
Comparative genomic sequencing is a major surveillance tool in the Polio Laboratory Network. Due to the rapid evolution of polioviruses (~1 % per year), pathways of virus transmission can be reconstructed from the pathways of genomic evolution. Here, we describe three main phylogenetic methods; estimation of genetic distances, reconstruction of a maximum-likelihood (ML) tree, and estimation of substitution rates using Bayesian Markov chain Monte Carlo (MCMC). The data set used consists of complete capsid sequences from a survey of poliovirus sequences available in GenBank.Entities:
Keywords: Bayesian MCMC; Maximum-likelihood; Phylogenetic analysis; Poliovirus evolution
Mesh：
Substances：
Year: 2016 PMID： 26983737 DOI： 10.1007/978-1-4939-3292-4_11
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745