| Literature DB >> 26982359 |
Karlynn E Neu1, Patrick C Wilson2.
Abstract
Germinal center (GC) responses are required for the generation of high-affinity antigen-specific B cells. Kuraoka et al. (2016) explore the importance of inter-clonal competition in GC affinity maturation through the use of complex immunizing antigens and discover an unexpected increase in clonal diversity over the course of the response.Mesh:
Substances:
Year: 2016 PMID: 26982359 DOI: 10.1016/j.immuni.2016.03.001
Source DB: PubMed Journal: Immunity ISSN: 1074-7613 Impact factor: 31.745