Literature DB >> 26980608

7-Chlorofolipastatin, an inhibitor of sterol O-acyltransferase, produced by marine-derived Aspergillus ungui NKH-007.

Ryuji Uchida1, Kento Nakajyo1, Keisuke Kobayashi1, Taichi Ohshiro1, Takeshi Terahara2, Chiaki Imada2, Hiroshi Tomoda1.   

Abstract

A new depsidone, named 7-chlorofolipastatin, and five known structurally related depsidones were isolated from the culture broth of the marine-derived fungus Aspergillus ungui NKM-007 by solvent extraction and HPLC using an octadecylsilyl column. The structure of 7-chlorofolipastatin was elucidated by various spectroscopic data including 1D and 2D NMR spectroscopy. 7-Chlorofolipastatin inhibited sterol O-acyltransferase (SOAT) 1 and 2 isozymes in cell-based and enzyme assays using SOAT1- and SOAT2-expressing Chinese hamster ovary (CHO) cells.

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Year:  2016        PMID： 26980608     DOI： 10.1038/ja.2016.27

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  19 in total

1.  Quantitative PCR analysis of selected Aspergillus, Penicillium and Paecilomyces species.

Authors:  Richard A Haugland; Manju Varma; Larry J Wymer; Stephen J Vesper
Journal:  Syst Appl Microbiol       Date:  2004-03       Impact factor: 4.022

Review 2.  Regulation of lipid droplet cholesterol efflux from macrophage foam cells.

Authors:  Mireille Ouimet; Yves L Marcel
Journal:  Arterioscler Thromb Vasc Biol       Date:  2011-12-29       Impact factor: 8.311

Review 3.  Acyl coenzyme A: cholesterol acyltransferase types 1 and 2: structure and function in atherosclerosis.

Authors:  L L Rudel; R G Lee; T L Cockman
Journal:  Curr Opin Lipidol       Date:  2001-04       Impact factor: 4.776

4.  Effects of the acyl coenzyme A:cholesterol acyltransferase inhibitor avasimibe on human atherosclerotic lesions.

Authors:  Jean-Claude Tardif; Jean Grégoire; Philippe L L'Allier; Todd J Anderson; Olivier Bertrand; Francois Reeves; Lawrence M Title; Fernando Alfonso; Erick Schampaert; Alita Hassan; Richard McLain; Milton L Pressler; Reda Ibrahim; Jacques Lespérance; John Blue; Therese Heinonen; Josep Rodés-Cabau
Journal:  Circulation       Date:  2004-11-08       Impact factor: 29.690

5.  Complete inhibition of mouse macrophage-derived foam cell formation by triacsin C.

Authors:  I Namatame; H Tomoda; H Arai; K Inoue; S Omura
Journal:  J Biochem       Date:  1999-02       Impact factor: 3.387

6.  ACAT inhibition and progression of carotid atherosclerosis in patients with familial hypercholesterolemia: the CAPTIVATE randomized trial.

Authors:  Marijn C Meuwese; Eric de Groot; Raphaël Duivenvoorden; Mieke D Trip; Leiv Ose; Frans J Maritz; Dick C G Basart; John J P Kastelein; Rafik Habib; Michael H Davidson; Aeilko H Zwinderman; Lee R Schwocho; Evan A Stein
Journal:  JAMA       Date:  2009-03-18       Impact factor: 56.272

7.  Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells.

Authors:  C C Chang; H Y Huh; K M Cadigan; T Y Chang
Journal:  J Biol Chem       Date:  1993-10-05       Impact factor: 5.157

8.  ACAT2 is localized to hepatocytes and is the major cholesterol-esterifying enzyme in human liver.

Authors:  Paolo Parini; Matthew Davis; Aaron T Lada; Sandra K Erickson; Teresa L Wright; Ulf Gustafsson; Staffan Sahlin; Curt Einarsson; Mats Eriksson; Bo Angelin; Hiroshi Tomoda; Satoshi Omura; Mark C Willingham; Lawrence L Rudel
Journal:  Circulation       Date:  2004-09-27       Impact factor: 29.690

9.  Effect of ACAT inhibition on the progression of coronary atherosclerosis.

Authors:  Steven E Nissen; E Murat Tuzcu; H Bryan Brewer; Ilke Sipahi; Stephen J Nicholls; Peter Ganz; Paul Schoenhagen; David D Waters; Carl J Pepine; Tim D Crowe; Michael H Davidson; John E Deanfield; Lisa M Wisniewski; James J Hanyok; Laurent M Kassalow
Journal:  N Engl J Med       Date:  2006-03-23       Impact factor: 91.245

10.  Identification of a form of acyl-CoA:cholesterol acyltransferase specific to liver and intestine in nonhuman primates.

Authors:  R A Anderson; C Joyce; M Davis; J W Reagan; M Clark; G S Shelness; L L Rudel
Journal:  J Biol Chem       Date:  1998-10-09       Impact factor: 5.157
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  7 in total

1.  Aspergone, a new chromanone derivative from fungus Aspergillus sp. SCSIO41002 derived of mangrove soil sample.

Authors:  Bin Yang; Huaming Tao; Xiao-Chu Qin; Zhen Wang; Junde Dong; Xiuping Lin; Xuefeng Zhou; Jian-Lin Li; Zheng-Chao Tu; Yonghong Liu
Journal:  J Antibiot (Tokyo)       Date:  2017-01-25       Impact factor: 2.649

2.  Curdepsidones B⁻G, Six Depsidones with Anti-Inflammatory Activities from the Marine-Derived Fungus Curvularia sp. IFB-Z10.

Authors:  Yi Ding; Faliang An; Xiaojing Zhu; Haiyuan Yu; Liling Hao; Yanhua Lu
Journal:  Mar Drugs       Date:  2019-05-05       Impact factor: 5.118

Review 3.  A Review: Halogenated Compounds from Marine Fungi.

Authors:  Cong Wang; Huanyun Lu; Jianzhou Lan; K H Ahammad Uz Zaman; Shugeng Cao
Journal:  Molecules       Date:  2021-01-16       Impact factor: 4.411

Review 4.  Metabolites of Marine Sediment-Derived Fungi: Actual Trends of Biological Activity Studies.

Authors:  Anton N Yurchenko; Elena V Girich; Ekaterina A Yurchenko
Journal:  Mar Drugs       Date:  2021-02-04       Impact factor: 5.118

Review 5.  Marine Pharmacology in 2016-2017: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action.

Authors:  Alejandro M S Mayer; Aimee J Guerrero; Abimael D Rodríguez; Orazio Taglialatela-Scafati; Fumiaki Nakamura; Nobuhiro Fusetani
Journal:  Mar Drugs       Date:  2021-01-21       Impact factor: 5.118

6.  A Mixture of Atropisomers Enhances Neutral Lipid Degradation in Mammalian Cells with Autophagy Induction.

Authors:  Keisuke Kobayashi; Satoshi Ohte; Taichi Ohshiro; Narihiro Ugaki; Hiroshi Tomoda
Journal:  Sci Rep       Date:  2018-08-14       Impact factor: 4.379

Review 7.  Deep-Sea Fungi Could Be the New Arsenal for Bioactive Molecules.

Authors:  Muhammad Zain Ul Arifeen; Yu-Nan Ma; Ya-Rong Xue; Chang-Hong Liu
Journal:  Mar Drugs       Date:  2019-12-20       Impact factor: 5.118
  7 in total

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