Literature DB >> 26980522

Biologic relativity: Who is the observer and what is observed?

John S Torday1, William B Miller2.   

Abstract

When quantum physics and biological phenomena are analogously explored, it emerges that biologic causation must also be understood independently of its overt appearance. This is similar to the manner in which Bohm characterized the explicate versus the implicate order as overlapping frames of ambiguity. Placed in this context, the variables affecting epigenetic inheritance can be properly assessed as a key mechanistic principle of evolution that significantly alters our understanding of homeostasis, pleiotropy, and heterochrony, and the purposes of sexual reproduction. Each of these become differing manifestations of a new biological relativity in which biologic space-time becomes its own frame. In such relativistic cellular contexts, it is proper to question exactly who has observer status, and who and what are being observed. Consideration within this frame reduces biology to cellular information sharing through cell-cell communication to resolve ambiguities at every scope and scale. In consequence, it becomes implicit that eukaryotic evolution derives from the unicellular state, remaining consistently adherent to it in a continuous evolutionary arc based upon elemental, non-stochastic physiologic first principles. Furthermore, the entire cell including its cytoskeletal apparatus and membranes that participate in the resolution of biological uncertainties must be considered as having equivalent primacy with genomes in evolutionary terms.
Copyright © 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Biologic relativity theory; Cell–cell communication; Evolution; Implicate order; Physiologic first principles; Quantum physics; Thought experiment; Unicell

Mesh:

Year:  2016        PMID: 26980522      PMCID: PMC4854779          DOI: 10.1016/j.pbiomolbio.2016.03.001

Source DB:  PubMed          Journal:  Prog Biophys Mol Biol        ISSN: 0079-6107            Impact factor:   3.667


  39 in total

1.  A quantum approach to visual consciousness.

Authors:  Nancy J. Woolf; Stuart R. Hameroff
Journal:  Trends Cogn Sci       Date:  2001-11-01       Impact factor: 20.229

Review 2.  Epigenetic reprogramming in mammals.

Authors:  Hugh D Morgan; Fátima Santos; Kelly Green; Wendy Dean; Wolf Reik
Journal:  Hum Mol Genet       Date:  2005-04-15       Impact factor: 6.150

Review 3.  Epigenetics and plant evolution.

Authors:  Ryan A Rapp; Jonathan F Wendel
Journal:  New Phytol       Date:  2005-10       Impact factor: 10.151

Review 4.  Epigenetic reprogramming of the male genome during gametogenesis and in the zygote.

Authors:  S Rousseaux; N Reynoird; E Escoffier; J Thevenon; C Caron; S Khochbin
Journal:  Reprod Biomed Online       Date:  2008-04       Impact factor: 3.828

5.  The systems view of man: implications for medicine, science, and ethics.

Authors:  H Brody
Journal:  Perspect Biol Med       Date:  1973       Impact factor: 1.416

Review 6.  The sex difference in fetal lung surfactant production.

Authors:  J S Torday; H C Nielsen
Journal:  Exp Lung Res       Date:  1987       Impact factor: 2.459

Review 7.  Hierarchical and cybernetic nature of biologic systems and their relevance to homeostatic adaptation to low-level exposures to oxidative stress-inducing agents.

Authors:  J E Trosko
Journal:  Environ Health Perspect       Date:  1998-02       Impact factor: 9.031

8.  Darwinian evolution in the light of genomics.

Authors:  Eugene V Koonin
Journal:  Nucleic Acids Res       Date:  2009-02-12       Impact factor: 16.971

9.  Evolution of energy metabolism, stem cells and cancer stem cells: how the warburg and barker hypotheses might be linked.

Authors:  James E Trosko; Kyung-Sun Kang
Journal:  Int J Stem Cells       Date:  2012-05       Impact factor: 2.500

Review 10.  The Microbiome: The Trillions of Microorganisms That Maintain Health and Cause Disease in Humans and Companion Animals.

Authors:  A Rodrigues Hoffmann; L M Proctor; M G Surette; J S Suchodolski
Journal:  Vet Pathol       Date:  2015-07-28       Impact factor: 2.221

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  2 in total

Review 1.  The resolution of ambiguity as the basis for life: A cellular bridge between Western reductionism and Eastern holism.

Authors:  John S Torday; William B Miller
Journal:  Prog Biophys Mol Biol       Date:  2017-07-22       Impact factor: 3.667

2.  A systematic approach to cancer: evolution beyond selection.

Authors:  William B Miller; John S Torday
Journal:  Clin Transl Med       Date:  2017-01-03
  2 in total

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