| Literature DB >> 26980007 |
Yi-Sun Song1, Jun-Ho Joe1, Hyun-Woo Joo1, In-Hwa Park1, Guang-Yin Shen2, Ki-Jun Kim1, Yonggu Lee3, Jeong Hun Shin2, Hyuck Kim4, Kyung-Soo Kim5,6.
Abstract
Granulocyte-colony stimulating factor (G-CSF) is widely known to have a neuroprotective effect, but its effects on function and morphology in mechanical nerve injury are not well understood. The aim of this study was to confirm the time course of the functional changes and morphological effects of G-CSF in a rat model of nerve crush injury. Twelve-eight rats were divided into three group: sham-operated control group, G-CSF-treated group, and saline treated group. 2 weeks after the nerve crush injury, G-CSF was injected for 5 days. After 4 weeks, functional tests such as motor nerve conduction velocity (MNCV), mechanical and cold allodynia tests, and morphological studies were performed. G-CSF-treated rats had significantly improved nerve function including MNCV and mechanical and cold allodynia. In addition, G-CSF-treated rats had significantly higher the density of myelinated fibers than saline-treated rats. In conclusion, we found that 100 μg/kg administration of G-CSF promoted long-term functional recovery in a rat model of nerve crush injury.Entities:
Keywords: Allodynia; Granulocyte-colony stimulating factor; Mechanical nerve injury; Nerve crush injury; Nerve function
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Year: 2016 PMID： 26980007 DOI： 10.1007/s11064-016-1879-z
Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996