S Meireles1, F De Groote2, N D Reeves3, S Verschueren4, C Maganaris5, F Luyten6, I Jonkers7. 1. Department of Kinesiology, KU Leuven, Belgium. Electronic address: susana.meireles@faber.kuleuven.be. 2. Department of Mechanical Engineering, KU Leuven, Belgium. Electronic address: Friedl.DeGroote@mech.kuleuven.be. 3. School of Healthcare Science, Manchester Metropolitan University, United Kingdom. Electronic address: N.Reeves@mmu.ac.uk. 4. Department of Rehabilitation Sciences, KU Leuven, Belgium. Electronic address: Sabine.Verschueren@faber.kuleuven.be. 5. School of Sport and Exercise Sciences, Liverpool John Moores University, United Kingdom. Electronic address: c.maganaris@ljmu.ac.uk. 6. Department of Development and Regeneration, KU Leuven, Belgium. Electronic address: frank.luyten@uz.kuleuven.ac.be. 7. Department of Kinesiology, KU Leuven, Belgium. Electronic address: ilse.jonkers@faber.kuleuven.be.
Abstract
OBJECTIVE: This study calculated knee contact forces (KCF) and its relations with knee external knee adduction moments (KAM) and/or flexion moments (KFM) during the stance phase of gait in patients with early osteoarthritis (OA), classified based on early joint degeneration on Magnetic Resonance Imaging (MRI). We aimed at assessing if altered KCF are already present in early structural degeneration. DESIGN: Three-dimensional motion and ground reaction force data in 59 subjects with medial compartment knee OA (N=23 established OA, N=16 early OA, N=20 controls) were used as input for a musculoskeletal model. KAM and KFM, and KCF were estimated using OpenSim software. RESULTS: No significant differences were found between controls and subjects with early OA. In early OA patients, KAM significantly explained 69% of the variance associated with the first peaks KCF but only KFM contributed to the second peaks KCF. The multiple correlation, combining KAM and KFM, showed to be higher. However, only 20% of the variance of second peak KCF was explained by both moments in established OA. CONCLUSION: KCF are not increased in patients with early OA, suggesting that knee joint overload is more a consequence of further joint degeneration in more advanced stages of OA. Additionally, our results clearly show that KAM is not sufficient to predict joint loading at the end of the stance, where KFM contributes substantially to the loading, especially in early OA.
OBJECTIVE: This study calculated knee contact forces (KCF) and its relations with knee external knee adduction moments (KAM) and/or flexion moments (KFM) during the stance phase of gait in patients with early osteoarthritis (OA), classified based on early joint degeneration on Magnetic Resonance Imaging (MRI). We aimed at assessing if altered KCF are already present in early structural degeneration. DESIGN: Three-dimensional motion and ground reaction force data in 59 subjects with medial compartment knee OA (N=23 established OA, N=16 early OA, N=20 controls) were used as input for a musculoskeletal model. KAM and KFM, and KCF were estimated using OpenSim software. RESULTS: No significant differences were found between controls and subjects with early OA. In early OA patients, KAM significantly explained 69% of the variance associated with the first peaks KCF but only KFM contributed to the second peaks KCF. The multiple correlation, combining KAM and KFM, showed to be higher. However, only 20% of the variance of second peak KCF was explained by both moments in established OA. CONCLUSION: KCF are not increased in patients with early OA, suggesting that knee joint overload is more a consequence of further joint degeneration in more advanced stages of OA. Additionally, our results clearly show that KAM is not sufficient to predict joint loading at the end of the stance, where KFM contributes substantially to the loading, especially in early OA.
Authors: Sam Van Rossom; Colin Robert Smith; Lianne Zevenbergen; Darryl Gerard Thelen; Benedicte Vanwanseele; Dieter Van Assche; Ilse Jonkers Journal: PLoS One Date: 2017-01-11 Impact factor: 3.240