Inge K Herrmann1,2,3, Beatrice Beck-Schimmer1,2, Christoph M Schumacher4, Sabrina Gschwind5, Andres Kaech6, Urs Ziegler6, Pierre-Alain Clavien7, Detlef Günther5, Wendelin J Stark4, Rolf Graf7, Andrea A Schlegel7. 1. Institute of Anesthesiology, University Hospital Zurich, Rämistrasse 100, CH-8091 Zurich, Switzerland. 2. Institute of Physiology & Zurich Center for Integrative Human Physiology, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland. 3. Department Materials Meet Life, Swiss Federal Laboratories for Materials Science & Technology (Empa), Lerchenfeldstrasse 5, 9014 St. Gallen, Switzerland. 4. ETH Zurich, Institute for Chemical & Bioengineering, Vladimir-Prelog-Weg 1-5/10, CH-8093 Zurich, Switzerland. 5. ETH Zurich, Laboratory of Inorganic Chemistry, Vladimir-Prelog-Weg 1-5/10, CH-8093 Zurich, Switzerland. 6. Center for Microscopy & Image Analysis, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland. 7. Swiss HPB & Transplant Center, Department of Surgery, University Hospital Zurich, Rämistrasse 100, CH-8091 Zurich, Switzerland.
Abstract
BACKGROUND: While carbon-encapsulated iron carbide nanoparticles exhibit strong magnetic properties appealing for biomedical applications, potential side effects of such materials remain comparatively poorly understood. Here, we assess the effects of iron-based nanoparticles in an in vivo long-term study in mice with observation windows between 1 week and 1 year. MATERIALS & METHODS: Functionalized (PEG or IgG) carbon-encapsulated platinum-spiked iron carbide nanoparticles were injected intravenously in mice (single or repeated dose administration). RESULTS: One week after administration, magnetic nanoparticles were predominantly localized in organs of the reticuloendothelial system, particularly the lung and liver. After 1 year, particles were still present in these organs, however, without any evident tissue alterations, such as inflammation, fibrosis, necrosis or carcinogenesis. Importantly, reticuloendothelial system organs presented with normal function. CONCLUSION: This long-term exposure study shows high in vivo compatibility of intravenously applied carbon-encapsulated iron nanoparticles suggesting continuing investigations on such materials for biomedical applications.
BACKGROUND: While carbon-encapsulated iron carbide nanoparticles exhibit strong magnetic properties appealing for biomedical applications, potential side effects of such materials remain comparatively poorly understood. Here, we assess the effects of iron-based nanoparticles in an in vivo long-term study in mice with observation windows between 1 week and 1 year. MATERIALS & METHODS: Functionalized (PEG or IgG) carbon-encapsulated platinum-spiked iron carbide nanoparticles were injected intravenously in mice (single or repeated dose administration). RESULTS: One week after administration, magnetic nanoparticles were predominantly localized in organs of the reticuloendothelial system, particularly the lung and liver. After 1 year, particles were still present in these organs, however, without any evident tissue alterations, such as inflammation, fibrosis, necrosis or carcinogenesis. Importantly, reticuloendothelial system organs presented with normal function. CONCLUSION: This long-term exposure study shows high in vivo compatibility of intravenously applied carbon-encapsulated iron nanoparticles suggesting continuing investigations on such materials for biomedical applications.
Entities:
Keywords:
blood purification; long-term study; magnetic nanoparticles; targeted drug delivery
Authors: Lykourgos Bougas; Lukas D Langenegger; Carlos A Mora; Martin Zeltner; Wendelin J Stark; Arne Wickenbrock; John W Blanchard; Dmitry Budker Journal: Sci Rep Date: 2018-02-22 Impact factor: 4.379