Sven Möbius-Winkler1, Madlen Uhlemann2, Volker Adams1, Marcus Sandri1, Sandra Erbs1, Karsten Lenk1, Norman Mangner1, Ulrike Mueller1, Jennifer Adam1, Martin Grunze1, Susanne Brunner1, Thomas Hilberg1, Meinhard Mende1, Axel P Linke1, Gerhard Schuler1. 1. From University of Leipzig, Heart Centre, Department of Internal Medicine/Cardiology, Germany (A.M.-W., M.U., V.A., M.S., S.E., K.L., N.M., U.M., J.A., A.P.L., G.S.); Asklepios Clinic Weißenfels, Germany (S.M.-W., K.L.); MediClin Dünenwald Klinik Trassenheide, Germany (M.G., S.B.); Department of Sports Medicine, University Wuppertal, Germany (T.H.); and Coordination Centre for Clinical Trials, University of Leipzig, Germany (M.M.). 2. From University of Leipzig, Heart Centre, Department of Internal Medicine/Cardiology, Germany (A.M.-W., M.U., V.A., M.S., S.E., K.L., N.M., U.M., J.A., A.P.L., G.S.); Asklepios Clinic Weißenfels, Germany (S.M.-W., K.L.); MediClin Dünenwald Klinik Trassenheide, Germany (M.G., S.B.); Department of Sports Medicine, University Wuppertal, Germany (T.H.); and Coordination Centre for Clinical Trials, University of Leipzig, Germany (M.M.). MadlenUhlemann@msn.com.
Abstract
BACKGROUND: A well-developed coronary collateral circulation provides a potential source of blood supply in coronary artery disease. However, the prognostic importance and functional relevance of coronary collaterals is controversial with the association between exercise training and collateral growth still unclear. METHODS AND RESULTS: This prospective, open-label study randomly assigned 60 patients with significant coronary artery disease (fractional flow reserve ≤0.75) to high-intensity exercise (group A, 20 patients) ormoderate-intensity exercise (group B, 20 patients) for 4 weeks or to a control group (group C, 20 patients). The primary end point was the change of the coronary collateral flow index (CFI) after 4 weeks. Analysis was based on the intention to treat. After 4 weeks, baseline CFI increased significantly by 39.4% in group A (from 0.142±0.07 at beginning to 0.198±0.09 at 4 weeks) in comparison with 41.3% in group B (from 0.143±0.06 to 0.202±0.09), whereas CFI in the control group remained unchanged (0.7%, from 0.149±0.09 to 0.150±0.08). High-intensity exercise did not lead to a greater CFI than moderate-intensity training. After 4 weeks, exercise capacity, Vo2 peak and ischemic threshold increased significantly in group A and group B in comparison with group C with no difference between group A and group B. CONCLUSIONS: A significant improvement in CFI was demonstrated in response to moderate- and high-intensity exercise performed for 10 hours per week. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01209637.
RCT Entities:
BACKGROUND: A well-developed coronary collateral circulation provides a potential source of blood supply in coronary artery disease. However, the prognostic importance and functional relevance of coronary collaterals is controversial with the association between exercise training and collateral growth still unclear. METHODS AND RESULTS: This prospective, open-label study randomly assigned 60 patients with significant coronary artery disease (fractional flow reserve ≤0.75) to high-intensity exercise (group A, 20 patients) or moderate-intensity exercise (group B, 20 patients) for 4 weeks or to a control group (group C, 20 patients). The primary end point was the change of the coronary collateral flow index (CFI) after 4 weeks. Analysis was based on the intention to treat. After 4 weeks, baseline CFI increased significantly by 39.4% in group A (from 0.142±0.07 at beginning to 0.198±0.09 at 4 weeks) in comparison with 41.3% in group B (from 0.143±0.06 to 0.202±0.09), whereas CFI in the control group remained unchanged (0.7%, from 0.149±0.09 to 0.150±0.08). High-intensity exercise did not lead to a greater CFI than moderate-intensity training. After 4 weeks, exercise capacity, Vo2 peak and ischemic threshold increased significantly in group A and group B in comparison with group C with no difference between group A and group B. CONCLUSIONS: A significant improvement in CFI was demonstrated in response to moderate- and high-intensity exercise performed for 10 hours per week. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01209637.