| Literature DB >> 26978781 |
Shingo Hatakeyama, Takuya Koie, Takuma Narita, Shogo Hosogoe, Hayato Yamamoto, Yuki Tobisawa, Tohru Yoneyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Chikara Ohyama.
Abstract
Entities:
Year: 2016 PMID: 26978781 PMCID: PMC4792434 DOI: 10.1371/journal.pone.0151742
Source DB: PubMed Journal: PLoS One ISSN: 1932-6203 Impact factor: 3.240
Clinical and pathological patient characteristics.
| All patients | Matched patients | |||||
|---|---|---|---|---|---|---|
| Incontinent | Continent | Incontinent | Continent | |||
| n | 47 | 68 | 34 | 34 | ||
| Ileal conduit / cutaneous ureterostomy, n = | 17 / 30 | 14 / 20 | ||||
| Median age | 67 (64–76) | 68 (58–71) | 66 (61–72) | 68 (58–71) | ||
| Gender | 39 / 8 | 47 / 21 | 26 / 8 | 27 / 7 | ||
| Mean ECOG-PS | 0.0±0.2 | 0.0±0.0 | 0.1±0.2 | 0.0±0.0 | ||
| Median follow-up, months (IQR) | 72 (53–112) | 97 (70–125) | 73 (54–98) | 101 (74–126) | ||
| Neoadjuvant chemotherapy, n = | 18 (38%) | 35 (51%) | 13 (38%) | 16 (47%) | ||
| TNM classification | ||||||
| cT | 2.4±0.9 | 2.3±0.8 | 2.4±0.9 | 2.2±0.8 | ||
| pT (±SD) | 2.1±1.2 | 1.4±1.2 | 2.0±1.2 | 1.3±1.1 | ||
| pN+, n = | 7 (15%) | 1 (1.5%) | 6 (18%) | 1 (3%) | ||
| Cardiovascular disease | 3 (6%) | 9 (13%) | 2 (6%) | 1 (3%) | ||
| Hypertension | 21 (45%) | 27 (40%) | 14 (41%) | 14 (41%) | ||
| Diabetes | 5 (11%) | 8 (12%) | 5 (15%) | 6 (18%) | ||
| Median blood loss, kg (IQR) | 1.5 (0.9–2.3) | 1.3 (0.9–2.0) | 1.4 (1.1–1.9) | 1.3 (0.9–1.6) | ||
| Median operative duration, hours (IQR) | 4.7 (4.0–6.3) | 5.0 (4.4–6.2) | 4.8 (4.0–6.2) | 4.8 (4.5–6.0) | ||
| Postoperative Complications, n = | 18 (38%) | 26 (38%) | 19 (56%) | 19 (56%) | ||
| Postoperative hydronephrosis (> G1), n = | 16 (34%) | 5 (7%) | 12 (35%) | 4 (12%) | ||
| Ureteral stent, n = | 23 (49%) | 0 (0%) | 15 (44%) | 0 (0%) | ||
| Ileal conduit, stent (+) | 2 (12%) | 1 (7%) | ||||
| Cutaneous ureterostomy, stent (+) | 21 (70%) | 14 (70%) | ||||
| Recurrence, n = | 15 (32%) | 6 (9%) | 10 (29%) | 2 (6%) | ||
| Chemotherapy for recurrent disease, n = | 14 (30%) | 4 (6%) | 9 (27%) | 1 (2.9%) | ||
| Median cycle (IQR) | 4 (2–6) | 4 (1–5) | 6 (3–14) | 3 (1–4) | ||
* applied for propensity score-matching SD, standard deviation; IQC, interquartile range.
Multivariate Cox regression analyses of risk factors for postoperative stage 3B CKD (eGFR < 45 mL/min/1.73 m2).
Incontinent urinary diversion was divided into 2 groups, and compared with orthotopic ileal neobladder in the model 2. Comorbidities included past history of CVD, HTN, or DM.
| Variables (Model 1) | Fisk factors | HR | 95%CI | |
|---|---|---|---|---|
| Age | Older than 67 years | 2.90 | 1.03–8.13 | |
| Comorbidities | Pre-existing | 2.40 | 0.82–7.02 | |
| eGFR before surgery | < 60 ml/min/1.73m2 | 3.25 | 1.20–8.80 | |
| Stent indwelling | Positive | 0.40 | 0.11–1.45 | |
| Postoperative hydronephrosis | Greater than grade 1 | 5.15 | 1.81–14.6 | |
| Tumor recurrence | Positive | 0.91 | 0.22–3.71 | |
| Chemotherapy for recurrent disease | Positive | 0.43 | 0.09–2.04 | |
| Urinary diversion | Incontinent diversion | 4.41 | 1.33–14.7 | |
| Age | Older than 67 years | 3.47 | 1.17–10.4 | |
| Comorbidities | Pre-existing | 2.32 | 0.78–6.87 | |
| eGFR before surgery | < 60 ml/min/1.73m2 | 3.32 | 1.25–8.82 | |
| Stent indwelling | Positive | 0.22 | 0.04–1.10 | |
| Postoperative hydronephrosis | Greater than grade 1 | 4.81 | 1.70–13.7 | |
| Tumor recurrence | Positive | 0.97 | 0.23–4.11 | |
| Chemotherapy for recurrent disease | Positive | 0.33 | 0.06–1.77 | |
| Urinary diversion (ref. neobladder) | Cutaneous ureterostomy | 8.92 | 1.63–48.7 | |
| Ileal conduit | 3.44 | 0.91–13.1 |