Literature DB >> 26977875

KLF4 Initiates Acinar Cell Reprogramming and Is Essential for the Early Stages of Pancreatic Carcinogenesis.

Ravikanth Maddipati1, Jonathan P Katz2.   

Abstract

Pancreatic ductal adenocarcinoma (PDA) has a dismal prognosis and is minimally responsive to current chemotherapies. In this issue of Cancer Cell, Xie et al. (2016) identify the transcription factor KLF4 as essential for the early stages of pancreatic carcinogenesis, expanding the repertoire of targets for early intervention strategies.
Copyright © 2016 Elsevier Inc. All rights reserved.

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Year:  2016        PMID： 26977875     DOI： 10.1016/j.ccell.2016.02.019

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  3 in total

1.  CRISPR-ON-Mediated KLF4 overexpression inhibits the proliferation, migration and invasion of urothelial bladder cancer in vitro and in vivo.

Authors:  Xin Xu; Jiangfeng Li; Yi Zhu; Bo Xie; Xiao Wang; Song Wang; Haiyun Xie; Huaqing Yan; Yufan Ying; Yiwei Lin; Ben Liu; Wei Wang; Xiangyi Zheng
Journal:  Oncotarget       Date:  2017-10-27

2.  KLF4, A Gene Regulating Prostate Stem Cell Homeostasis, Is a Barrier to Malignant Progression and Predictor of Good Prognosis in Prostate Cancer.

Authors:  Xiaozhong Xiong; Markus Schober; Evelyne Tassone; Alireza Khodadadi-Jamayran; Ana Sastre-Perona; Hua Zhou; Aristotelis Tsirigos; Steven Shen; Miao Chang; Jonathan Melamed; Liliana Ossowski; Elaine L Wilson
Journal:  Cell Rep       Date:  2018-12-11       Impact factor: 9.423

3.  Secretory Mucin 5AC Promotes Neoplastic Progression by Augmenting KLF4-Mediated Pancreatic Cancer Cell Stemness.

Authors:  Koelina Ganguly; Shiv Ram Krishn; Satyanarayana Rachagani; Rahat Jahan; Ashu Shah; Palanisamy Nallasamy; Sanchita Rauth; Pranita Atri; Jesse L Cox; Ramesh Pothuraju; Lynette M Smith; Sudhua Ayala; Christopher Evans; Moorthy P Ponnusamy; Sushil Kumar; Sukhwinder Kaur; Surinder K Batra
Journal:  Cancer Res       Date:  2020-10-30       Impact factor: 13.312
  3 in total

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