Guangdong Qiao1, Yizi Cong1, Haidong Zou1, Jun Lin1, Xingmiao Wang1, Xiaohui Li1, Yalun Li1, Shiguang Zhu2. 1. Department of Breast Surgery, Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University, Yantai, Shandong, P.R. China. 2. Department of Breast Surgery, Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University, Yantai, Shandong, P.R. China ytzhushiguang@medmail.com.cn.
Abstract
AIM: This study aimed to investigate the accuracy of frozen section (FS) in diagnosis of sentinel lymph node metastasis and to analyze the predictive factors for false-negativity. PATIENTS AND METHODS: Patients with breast cancer and clinically negative axillary were recruited for sentinel lymph node biopsy (SLNB). All nodes were examined by intraoperative FS and underwent further paraffin sectioning. RESULTS: A total of 1,272 patients underwent SLNB over an 8-year period, and 53 patients had false-negative FS. Univariate and multivariate analysis revealed that younger age, stellate mammographic pattern, and ER-positive status were statistically different when compared to the 53 members of the cohort who were truly negative on SLNB (control group). Eight patients were lost to clinical follow-up; the recurrence-free survival rate of the remaining 49 patients with false-negative SLNB did not differ from that of the 49-patient cohort (control group) (p=0.072), while these patients did experience poorer overall survival (p=0.035). CONCLUSION: Younger age, stellate mammographic pattern and ER-positive status were independent predictors for false-negative FS on biopsy. Copyright
AIM: This study aimed to investigate the accuracy of frozen section (FS) in diagnosis of sentinel lymph node metastasis and to analyze the predictive factors for false-negativity. PATIENTS AND METHODS: Patients with breast cancer and clinically negative axillary were recruited for sentinel lymph node biopsy (SLNB). All nodes were examined by intraoperative FS and underwent further paraffin sectioning. RESULTS: A total of 1,272 patients underwent SLNB over an 8-year period, and 53 patients had false-negative FS. Univariate and multivariate analysis revealed that younger age, stellate mammographic pattern, and ER-positive status were statistically different when compared to the 53 members of the cohort who were truly negative on SLNB (control group). Eight patients were lost to clinical follow-up; the recurrence-free survival rate of the remaining 49 patients with false-negative SLNB did not differ from that of the 49-patient cohort (control group) (p=0.072), while these patients did experience poorer overall survival (p=0.035). CONCLUSION: Younger age, stellate mammographic pattern and ER-positive status were independent predictors for false-negative FS on biopsy. Copyright
Authors: Anne Grabenstetter; Tracy-Ann Moo; Sabina Hajiyeva; Peter J Schüffler; Pallavi Khattar; Maria A Friedlander; Maura A McCormack; Monica Raiss; Emily C Zabor; Andrea Barrio; Monica Morrow; Marcia Edelweiss Journal: Am J Surg Pathol Date: 2019-10 Impact factor: 6.394
Authors: Florian Reinhardt; Anna Fiedler; Felix Borgmeier; Petra Reinecke; Irene Esposito; Katalin Mattes-György; Mardjan Dabir; Verena Friebe; Natalia Krawczyk; Thomas Kaleta; Jürgen Hoffmann; Eugen Ruckhäberle; Tanja Fehm; Katrin S Roth; Svjetlana Mohrmann Journal: Geburtshilfe Frauenheilkd Date: 2022-06-03 Impact factor: 2.754