Joanna Kacperczyk1, Paweł Bartnik2, Ewa Romejko-Wolniewicz3, Katarzyna Jalinik3. 1. Students' Scientific Group affiliated to the Second Department of Obstetrics and Gynecology, Medical University of Warsaw, Warsaw, Poland asiakacperczyk@gmail.com. 2. Students' Scientific Group affiliated to the Second Department of Obstetrics and Gynecology, Medical University of Warsaw, Warsaw, Poland. 3. Second Department of Obstetrics and Gynecology, Medical University of Warsaw, Warsaw, Poland.
Abstract
BACKGROUND: Atypical squamous cells of undetermined significance (ASCUS) and low-grade squamous intraepithelial lesion (LSIL) are the two most common results of positive Pap smears. AIM: The aim of this study was to compare the management of patients with ASCUS and LSIL. PATIENTS AND METHODS: All procedures were performed between 2003 and 2014 in an outpatient clinic affiliated to a tertiary referral center, and included Pap smears, colposcopy, histology and invasive treatment. RESULTS: There were 131 patients in the ASCUS group and 84 in the LSIL group. Further negative cytological results were obtained more frequently among the ASCUS group than the LSIL group [relative risk (RR)=1.18, 95% confidence interval (CI)=1.33-2.40; p<0.001]. Histological results revealed higher occurrence of cervical intraepithelial neoplasia grade III or invasive squamous cancer in the LSIL group than the ASCUS group [RR=6.8 (95% CI=0.95-144.63), p=0.033]. Patients from the LSIL group more frequently required invasive treatment [RR=2.53, 95% CI=1.40-4.67, p=0.001]. CONCLUSION: Diagnosis of ASCUS is associated with more frequent cases of total remission in follow-up Pap smears and requires for less-invasive management. Copyright
BACKGROUND: Atypical squamous cells of undetermined significance (ASCUS) and low-grade squamous intraepithelial lesion (LSIL) are the two most common results of positive Pap smears. AIM: The aim of this study was to compare the management of patients with ASCUS and LSIL. PATIENTS AND METHODS: All procedures were performed between 2003 and 2014 in an outpatient clinic affiliated to a tertiary referral center, and included Pap smears, colposcopy, histology and invasive treatment. RESULTS: There were 131 patients in the ASCUS group and 84 in the LSIL group. Further negative cytological results were obtained more frequently among the ASCUS group than the LSIL group [relative risk (RR)=1.18, 95% confidence interval (CI)=1.33-2.40; p<0.001]. Histological results revealed higher occurrence of cervical intraepithelial neoplasia grade III or invasive squamous cancer in the LSIL group than the ASCUS group [RR=6.8 (95% CI=0.95-144.63), p=0.033]. Patients from the LSIL group more frequently required invasive treatment [RR=2.53, 95% CI=1.40-4.67, p=0.001]. CONCLUSION: Diagnosis of ASCUS is associated with more frequent cases of total remission in follow-up Pap smears and requires for less-invasive management. Copyright
Authors: Asrar Mohammed Abdullah Abdulaziz; Lu Liu; Yu Sun; Xuewu You; Baoxia Cui; Sai Han; Youzhong Zhang Journal: Int J Clin Exp Pathol Date: 2020-02-01