| Literature DB >> 26976812 |
Mohammadmajid Sepantafar1, Reihan Maheronnaghsh2, Hossein Mohammadi3, Sareh Rajabi-Zeleti4, Nasim Annabi5, Nasser Aghdami6, Hossein Baharvand7.
Abstract
One of the major problems in the treatment of cardiovascular diseases is the inability of myocardium to self-regenerate. Current therapies are unable to restore the heart's function after myocardial infarction. Myocardial tissue engineering is potentially a key approach to regenerate damaged heart muscle. Myocardial patches are applied surgically, whereas injectable hydrogels provide effective minimally invasive approaches to recover functional myocardium. These hydrogels are easily administered and can be either cell free or loaded with bioactive agents and/or cardiac stem cells, which may apply paracrine effects. The aim of this review is to investigate the advantages and disadvantages of injectable stem cell-laden hydrogels and highlight their potential applications for myocardium repair.Entities:
Keywords: Infarction; Injectable hydrogel; Myocardial tissue engineering; Regeneration; Stem cell transplantation
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Year: 2016 PMID： 26976812 DOI： 10.1016/j.biotechadv.2016.03.003
Source DB: PubMed Journal: Biotechnol Adv ISSN： 0734-9750 Impact factor: 14.227