Edward Vigmond1, Ali Pashaei2, Sana Amraoui3, Hubert Cochet4, Michel Hassaguerre4. 1. L'Institut de Rythmologie et Modélisation Cardiaque LIRYC, Fondation Université de Bordeaux, Hôpital Xavier-Arnozan, Pessac, France; Institut de Mathématiques de Bordeaux, Université de Bordeaux, Talence, France. Electronic address: edward.vigmond@u-bordeaux.fr. 2. L'Institut de Rythmologie et Modélisation Cardiaque LIRYC, Fondation Université de Bordeaux, Hôpital Xavier-Arnozan, Pessac, France; Institut de Mathématiques de Bordeaux, Université de Bordeaux, Talence, France. 3. L'Institut de Rythmologie et Modélisation Cardiaque LIRYC, Fondation Université de Bordeaux, Hôpital Xavier-Arnozan, Pessac, France; Hôpital cardiologique de Haut- Lévèque, Pessac, France. 4. L'Institut de Rythmologie et Modélisation Cardiaque LIRYC, Fondation Université de Bordeaux, Hôpital Xavier-Arnozan, Pessac, France; Centre de Recherche Cardio-Thoracique de Bordeaux U1045,Université de Bordeaux, Bordeaux, France; Hôpital cardiologique de Haut- Lévèque, Pessac, France.
Abstract
BACKGROUND: Complex fractionated atrial electrograms (CFAEs) have long been associated with proarrhythmic alterations in atrial structure or electrophysiology. Structural alterations disrupt and slow smoothly propagating wavefronts, leading to wavebreaks and electrogram (EGM) fractionation, but the exact nature and characteristics for arrhythmia remain unknown. Clinically, in atrial fibrillation (AF) patients, increases in frequency, whether by pacing or fibrillation, increase EGM fractionation and duration, and reentry can occur in relation with the conduction disturbance. Recently, percolation has been proposed as an arrhythmogenic mechanism, but its role in AF has not been investigated. OBJECTIVE: We sought to determine if percolation can explain reentry formation and EGM behavior observed in AF patients. METHODS: Computer models of fibrotic tissue with different densities were generated based on late gadolinium-enhanced magnetic resonance images, using pixel intensity as a fibrosis probability to avoid an arbitrary binary threshold. Clinical pacing protocols were followed to induce AF, and EGMs were computed. RESULTS: Reentry could be elicited, with a biphasic behavior dependent on fibrotic density. CFAEs were recorded above fibrotic regions, and consistent with clinical data, EGM duration and fractionation increased with more rapid pacing. CONCLUSION: These findings confirm percolation as a potential mechanism to explain AF in humans and give new insights into dynamics underlying conduction distortions and fractionated signals in excitable media, which correlate well with the experimental findings in fibrotic regions. The greater understanding of the different patterns of conduction changes and related EGMs could lead to more individualized and effective approaches to AF ablation therapy.
BACKGROUND: Complex fractionated atrial electrograms (CFAEs) have long been associated with proarrhythmic alterations in atrial structure or electrophysiology. Structural alterations disrupt and slow smoothly propagating wavefronts, leading to wavebreaks and electrogram (EGM) fractionation, but the exact nature and characteristics for arrhythmia remain unknown. Clinically, in atrial fibrillation (AF) patients, increases in frequency, whether by pacing or fibrillation, increase EGM fractionation and duration, and reentry can occur in relation with the conduction disturbance. Recently, percolation has been proposed as an arrhythmogenic mechanism, but its role in AF has not been investigated. OBJECTIVE: We sought to determine if percolation can explain reentry formation and EGM behavior observed in AFpatients. METHODS: Computer models of fibrotic tissue with different densities were generated based on late gadolinium-enhanced magnetic resonance images, using pixel intensity as a fibrosis probability to avoid an arbitrary binary threshold. Clinical pacing protocols were followed to induce AF, and EGMs were computed. RESULTS: Reentry could be elicited, with a biphasic behavior dependent on fibrotic density. CFAEs were recorded above fibrotic regions, and consistent with clinical data, EGM duration and fractionation increased with more rapid pacing. CONCLUSION: These findings confirm percolation as a potential mechanism to explain AF in humans and give new insights into dynamics underlying conduction distortions and fractionated signals in excitable media, which correlate well with the experimental findings in fibrotic regions. The greater understanding of the different patterns of conduction changes and related EGMs could lead to more individualized and effective approaches to AF ablation therapy.
Authors: Caroline H Roney; Jason D Bayer; Sohail Zahid; Marianna Meo; Patrick M J Boyle; Natalia A Trayanova; Michel Haïssaguerre; Rémi Dubois; Hubert Cochet; Edward J Vigmond Journal: Europace Date: 2016-12 Impact factor: 5.214
Authors: Edward J Ciaccio; Elaine Y Wan; Deepak S Saluja; U Rajendra Acharya; Nicholas S Peters; Hasan Garan Journal: Comput Methods Programs Biomed Date: 2019-06-15 Impact factor: 5.428
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