Literature DB >> 26975859

PET Imaging Study of S1PR1 Expression in a Rat Model of Multiple Sclerosis.

Hui Liu1, Hongjun Jin1, Xuyi Yue1, Zonghua Luo1, Chunling Liu1, Adam J Rosenberg1, Zhude Tu2.   

Abstract

PURPOSE: Upregulation of sphingosine-1-phosphate receptor 1 (S1PR1) expression in multiple sclerosis (MS) lesions is associated with neuroinflammatory response. This study investigated the correlation between neuroinflammation and S1PR1 expression in the spinal cord of an experimental autoimmune encephalomyelitis (EAE) rat model of MS, using the S1PR1 positron emission tomography (PET) radiotracer [(11)C]TZ3321. PROCEDURES: MicroPET imaging studies of [(11)C]TZ3321 were performed to measure uptake of [(11)C]TZ3321 in the spinal cord of EAE rats. Immunohistochemical staining was performed to confirm the overexpression of S1PR1 and other inflammatory biomarkers.
RESULTS: MicroPET imaging demonstrated a 20-30 % increase in [(11)C]TZ3321 uptake in the lumbar spinal cord of EAE rats versus sham controls at 35-60 min post injection. The increased uptake of [(11)C]TZ3321 was correlated with the overexpression of S1PR1 in the lumbar spinal cord of EAE rats that was confirmed by immunohistochemical staining. Upregulated S1PR1 expression was associated with glial cell activation and immune cell infiltration.
CONCLUSIONS: MicroPET imaging modality with a specific radioligand [(11)C]TZ3321 is able to assess the expression of S1PR1 in EAE rat lumbar spinal cord. This may provide a new approach to the assessment of neuroinflammatory response in MS and other inflammatory diseases.

Entities:  

Keywords:  Experimental autoimmune encephalomyelitis; Multiple sclerosis; Neuroinflammation; PET imaging; Radiotracer; Sphingosine-1-phosphate receptor 1

Mesh：

Substances：

Year:  2016        PMID： 26975859      PMCID： PMC5297893          DOI： 10.1007/s11307-016-0944-y

Source DB:  PubMed          Journal:  Mol Imaging Biol        ISSN： 1536-1632            Impact factor:   3.488


  39 in total

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Authors:  Ruben Van Doorn; Jack Van Horssen; Dennis Verzijl; Maarten Witte; Eric Ronken; Bert Van Het Hof; Kim Lakeman; Christine D Dijkstra; Paul Van Der Valk; Arie Reijerkerk; Astrid E Alewijnse; Stephan L M Peters; Helga E De Vries
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3.  Imaging microglial/macrophage activation in spinal cords of experimental autoimmune encephalomyelitis rats by positron emission tomography using the mitochondrial 18 kDa translocator protein radioligand [¹⁸F]DPA-714.

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9.  The distribution of inflammatory demyelinated lesions in the central nervous system of rats with antibody-augmented demyelinating experimental allergic encephalomyelitis.

Authors:  A P Meeson; S Piddlesden; B P Morgan; R Reynolds
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10.  Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2.

Authors:  L Izikson; R S Klein; I F Charo; H L Weiner; A D Luster
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  21 in total

Review 1.  The Role of Advanced Magnetic Resonance Imaging Techniques in Multiple Sclerosis Clinical Trials.

Authors:  Kedar R Mahajan; Daniel Ontaneda
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2.  Pharmacologic characterizations of a P2X7 receptor-specific radioligand, [11C]GSK1482160 for neuroinflammatory response.

Authors:  Junbin Han; Hui Liu; Chunling Liu; Hongjun Jin; Joel S Perlmutter; Terrance M Egan; Zhude Tu
Journal:  Nucl Med Commun       Date:  2017-05       Impact factor: 1.690

3.  Syntheses and in vitro biological evaluation of S1PR1 ligands and PET studies of four F-18 labeled radiotracers in the brain of nonhuman primates.

Authors:  Zonghua Luo; Junbin Han; Hui Liu; Adam J Rosenberg; Delphine L Chen; Robert J Gropler; Joel S Perlmutter; Zhude Tu
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4.  Upregulated Sphingosine 1-Phosphate Receptor 1 Expression in Human and Murine Atherosclerotic Plaques.

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5.  Automated production of a sphingosine-1 phosphate receptor 1 (S1P1) PET radiopharmaceutical [11C]CS1P1 for human use.

Authors:  Zonghua Luo; Jiwei Gu; Robert C Dennett; Gregory G Gaehle; Joel S Perlmutter; Delphine L Chen; Tammie L S Benzinger; Zhude Tu
Journal:  Appl Radiat Isot       Date:  2019-06-20       Impact factor: 1.513

6.  Acute Rodent Tolerability, Toxicity, and Radiation Dosimetry Estimates of the S1P1-Specific Radioligand [11C]CS1P1.

Authors:  Hui Liu; Richard Laforest; Jiwei Gu; Zonghua Luo; Lynne A Jones; Robert J Gropler; Tammie L S Benzinger; Zhude Tu
Journal:  Mol Imaging Biol       Date:  2020-04       Impact factor: 3.488

7.  Radiosynthesis and evaluation of a fluorine-18 radiotracer [18F]FS1P1 for imaging sphingosine-1-phosphate receptor 1.

Authors:  Lin Qiu; Hao Jiang; Yanbo Yu; Jiwei Gu; Jinzhi Wang; Haiyang Zhao; Tianyu Huang; Robert J Gropler; Robyn S Klein; Joel S Perlmutter; Zhude Tu
Journal:  Org Biomol Chem       Date:  2022-02-02       Impact factor: 3.876

8.  Cholinergic imbalance in lumbar spinal cord of a rat model of multiple sclerosis.

Authors:  Chunling Liu; Hui Liu; Hongjun Jin; Xuyi Yue; Zonghua Luo; Zhude Tu
Journal:  J Neuroimmunol       Date:  2018-02-12       Impact factor: 3.478

9.  Syntheses and in vitro evaluation of new S1PR1 compounds and initial evaluation of a lead F-18 radiotracer in rodents.

Authors:  Zonghua Luo; Adam J Rosenberg; Hui Liu; Junbin Han; Zhude Tu
Journal:  Eur J Med Chem       Date:  2018-03-14       Impact factor: 6.514

10.  Design, Synthesis, and In Vitro and In Vivo Evaluation of an (18)F-Labeled Sphingosine 1-Phosphate Receptor 1 (S1P1) PET Tracer.

Authors:  Adam J Rosenberg; Hui Liu; Hongjun Jin; Xuyi Yue; Sean Riley; Steven J Brown; Zhude Tu
Journal:  J Med Chem       Date:  2016-06-22       Impact factor: 7.446
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