Pilar Sanchis1, Juan Manuel Buades2, Francisco Berga3, Miguel Mas Gelabert4, Marilisa Molina2, María Victoria Íñigo2, Susana García2, Jorge Gonzalez2, Maria Rosario Bernabeu2, Antonia Costa-Bauzá3, Felix Grases3. 1. Nephrology Department, Research Unit, Institute of Health Sciences Research (IUNICS-IdISPa), Hospital Son Llàtzer, Palma of Mallorca, Spain; Laboratory of Renal Lithiasis Research, Institute of Health Sciences Research (IUNICS-IdISPa), Department of Chemistry, University of Balearic Islands, Palma of Mallorca, Spain. Electronic address: pilar.sanchis@uib.es. 2. Nephrology Department, Research Unit, Institute of Health Sciences Research (IUNICS-IdISPa), Hospital Son Llàtzer, Palma of Mallorca, Spain. 3. Laboratory of Renal Lithiasis Research, Institute of Health Sciences Research (IUNICS-IdISPa), Department of Chemistry, University of Balearic Islands, Palma of Mallorca, Spain. 4. Radiology Department, Hospital Son Llàtzer, Palma of Mallorca, Spain.
Abstract
OBJECTIVE: The aim of this study was to evaluate the relationship between physiological levels of myo-inositol hexaphosphate (phytate) and cardiovascular (CV) calcification in patients with chronic kidney disease (CKD). DESIGN AND METHODS: This was a prospective cross-sectional study conducted from December 2012 to June 2013. SUBJECTS: Sixty-nine consecutive patients with CKD who were not undergoing renal replacement therapy. INTERVENTION: All subjects were given lateral lumbar X-rays to quantify abdominal aortic calcification (AAC). Clinical laboratory analyses and phytate food frequency questionnaires were also performed. MAIN OUTCOME MEASURE: Phytate urinary excretion, estimated phytate consumption (based on food frequency questionnaire) and AAC score. Patients were divided into two groups based on median abdominal aortic calcification (AAC) score: no/mild AAC (AAC ≤ 6, n = 35) and moderate/severe AAC (AAC > 6, n = 34). RESULTS: Patients with no/mild AAC were younger, had lower pulse pressure, greater dietary intake of phytate, greater urinary phytate and the prevalence of prior CV disease was significantly lower compared to patients with moderate/severe AAC. Among the top 10 phytate-rich foods, lentil consumption was significantly greater in patients with no/mild AAC than in those with moderate/severe AAC. Multivariate logistic regression analysis indicated that age, prior CV disease, urinary phytate (or lentil consumption) were independently associated to AAC. CONCLUSION: Our results suggest that adequate consumption of phytate can prevent AAC in patients with CKD. Further prospective studies must be performed to elucidate the benefits of a phytate-rich diet and the associated risk of phosphorus bioavailability in these patients.
OBJECTIVE: The aim of this study was to evaluate the relationship between physiological levels of myo-inositol hexaphosphate (phytate) and cardiovascular (CV) calcification in patients with chronic kidney disease (CKD). DESIGN AND METHODS: This was a prospective cross-sectional study conducted from December 2012 to June 2013. SUBJECTS: Sixty-nine consecutive patients with CKD who were not undergoing renal replacement therapy. INTERVENTION: All subjects were given lateral lumbar X-rays to quantify abdominal aortic calcification (AAC). Clinical laboratory analyses and phytate food frequency questionnaires were also performed. MAIN OUTCOME MEASURE: Phytate urinary excretion, estimated phytate consumption (based on food frequency questionnaire) and AAC score. Patients were divided into two groups based on median abdominal aortic calcification (AAC) score: no/mild AAC (AAC ≤ 6, n = 35) and moderate/severe AAC (AAC > 6, n = 34). RESULTS:Patients with no/mild AAC were younger, had lower pulse pressure, greater dietary intake of phytate, greater urinary phytate and the prevalence of prior CV disease was significantly lower compared to patients with moderate/severe AAC. Among the top 10 phytate-rich foods, lentil consumption was significantly greater in patients with no/mild AAC than in those with moderate/severe AAC. Multivariate logistic regression analysis indicated that age, prior CV disease, urinary phytate (or lentil consumption) were independently associated to AAC. CONCLUSION: Our results suggest that adequate consumption of phytate can prevent AAC in patients with CKD. Further prospective studies must be performed to elucidate the benefits of a phytate-rich diet and the associated risk of phosphorus bioavailability in these patients.
Authors: Joan Perelló; M Gómez; M D Ferrer; N Y Rodríguez; C Salcedo; J M Buades; M M Pérez; J V Torregrosa; E Martín; F Maduell Journal: J Nephrol Date: 2018-01-19 Impact factor: 3.902
Authors: Pilar Sanchis; Marilisa Molina; Francisco Berga; Elena Muñoz; Regina Fortuny; Antonia Costa-Bauzá; Felix Grases; Juan Manuel Buades Journal: Nutrients Date: 2019-12-25 Impact factor: 5.717