Matteo Franchi1, Marilù Giacalone2, Ippolito Traupe3, Rocco Rago4, Giacomo Baldi5, Francesco Giunta6, Francesco Forfori7. 1. University of Pisa, 56126 Pisa, Italy. Electronic address: matteoals@gmail.com. 2. University of Pisa, 56126 Pisa, Italy. Electronic address: marilugiacalone@gmail.com. 3. University of Pisa, 56126 Pisa, Italy. Electronic address: ippolito82@hotmail.it. 4. Department of Anesthesia and Intensive Care, Azienda Ospedaliera Universitaria Pisana, 56124 Pisa, Italy. Electronic address: r.rago@ao-pisa.toscana.it. 5. University of Pisa, 56126 Pisa, Italy. Electronic address: giacomo.baldi@gmail.com. 6. University of Pisa, 56126 Pisa, Italy; Department of Anesthesia and Intensive Care, Azienda Ospedaliera Universitaria Pisana, 56124 Pisa, Italy. Electronic address: fgiunta@med.unipi.it. 7. University of Pisa, 56126 Pisa, Italy; Department of Anesthesia and Intensive Care, Azienda Ospedaliera Universitaria Pisana, 56124 Pisa, Italy. Electronic address: francescoforfori@gmail.com.
Abstract
PURPOSE: Septic shock involves a dysregulation of the immune response to an infection. This may lead to hemodynamic dysfunction and multiple-organ failure. The main aim of this study was to evaluate the effect of coupled plasma filtration adsorption (CPFA) on the hemodynamic profile in patients with septic shock. MATERIALS AND METHODS: We retrospectively analyzed data from 21 adult patients admitted to the intensive care unit with a diagnosis of septic shock, comparing data between pre-CPFA and post-CPFA treatment. They received a maximum of 5 cycles of treatment. RESULTS: Coupled plasma filtration adsorption treatment was associated with a significant increase of mean arterial pressure (P < .001), reduction of the vasoactive/inotropic requirement (P = .007), and renal improvement. In patients with leukocytosis or leucopenia, the leukocyte count was restored to a reference range of values. CONCLUSION: Treatment with CPFA improves hemodynamic parameters in septic shock patients, ameliorating organ failure.
PURPOSE:Septic shock involves a dysregulation of the immune response to an infection. This may lead to hemodynamic dysfunction and multiple-organ failure. The main aim of this study was to evaluate the effect of coupled plasma filtration adsorption (CPFA) on the hemodynamic profile in patients with septic shock. MATERIALS AND METHODS: We retrospectively analyzed data from 21 adult patients admitted to the intensive care unit with a diagnosis of septic shock, comparing data between pre-CPFA and post-CPFA treatment. They received a maximum of 5 cycles of treatment. RESULTS: Coupled plasma filtration adsorption treatment was associated with a significant increase of mean arterial pressure (P < .001), reduction of the vasoactive/inotropic requirement (P = .007), and renal improvement. In patients with leukocytosis or leucopenia, the leukocyte count was restored to a reference range of values. CONCLUSION: Treatment with CPFA improves hemodynamic parameters in septic shockpatients, ameliorating organ failure.
Authors: Elena Garbero; Sergio Livigni; Fiorenza Ferrari; Stefano Finazzi; Martin Langer; Paolo Malacarne; Manlio Cosimo Claudio Meca; Sabino Mosca; Carlo Olivieri; Marco Pozzato; Carlotta Rossi; Mario Tavola; Marina Terzitta; Bruno Viaggi; Guido Bertolini Journal: Intensive Care Med Date: 2021-10-03 Impact factor: 17.440