Literature DB >> 26975

Long-term changes in dopaminergic innervation of caudate nucleus after continuous amphetamine administration.

G Ellison, M S Eison, H S Huberman, F Daniel.   

Abstract

Silicone pellets containing d-amphetamine base were implanted subcutaneously in rats. These pellets release amphetamine continuously for at least 10 days. Several days after implantation, swollen dopamine axons concomitant with large decreases in tyrosine hydroxylase activity were observed in the caudate nucleus. Decreased tyrosine hydroxylase activity was still present 110 days after pellet removal in the caudate but not in several other brain regions, nor in the caudate of rats injected with an equivalent amount of amphetamine in daily injections. This implies that continuous amphetamine administration has a selective neurotoxic effect on dopamine terminals in the caudate.

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Year:  1978        PMID： 26975     DOI： 10.1126/science.26975

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  43 in total

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2.  Selective neurotoxins, chemical tools to probe the mind: the first thirty years and beyond.

Authors:  R M Kostrzewa
Journal:  Neurotox Res       Date:  1999-09       Impact factor: 3.911

Review 3.  Neuroprotective effect of atypical antipsychotics in cognitive and non-cognitive behavioral impairment in animal models.

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Journal:  Cell Adh Migr       Date:  2009-01-13       Impact factor: 3.405

4.  Different glial response to methamphetamine- and methylenedioxymethamphetamine-induced neurotoxicity.

Authors:  David Pubill; Anna M Canudas; Mercè Pallàs; Antonio Camins; Jorge Camarasa; Elena Escubedo
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2003-04-09       Impact factor: 3.000

5.  Lack of effect of kappa-opioid receptor agonism on long-term methamphetamine-induced neurotoxicity in rats.

Authors:  Kamisha L Johnson-Davis; Glen R Hanson; Kristen A Keefe
Journal:  Neurotox Res       Date:  2003       Impact factor: 3.911

6.  Dopamine modulates the susceptibility of striatal neurons to 3-nitropropionic acid in the rat model of Huntington's disease.

Authors:  D S Reynolds; R J Carter; A J Morton
Journal:  J Neurosci       Date:  1998-12-01       Impact factor: 6.167

7.  Selective (+)-amphetamine neurotoxicity on striatal dopamine nerve terminals in the mouse.

Authors:  G Jonsson; E Nwanze
Journal:  Br J Pharmacol       Date:  1982-10       Impact factor: 8.739

8.  Effects of acute and chronic lithium treatment on amphetamine-induced dopamine increase in the nucleus accumbens and prefrontal cortex in rats as studied by microdialysis.

Authors:  T Baptista; L Teneúd; Q Contreras; J L Burguera; M Burguera; L Hernández
Journal:  J Neural Transm Gen Sect       Date:  1993

9.  Effects of antipsychotic drugs on the long-term effects of amphetamine on nigro-striatal dopamine neurons in iprindole-treated rats.

Authors:  L R Steranka
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-03       Impact factor: 3.000

10.  Reduction of 3H-spiroperidol binding in rat striatum and frontal cortex by chronic amphetamine: dose response, time course and role of sustained dopamine release.

Authors:  E B Nielsen; M Nielsen; C Braestrup
Journal:  Psychopharmacology (Berl)       Date:  1983       Impact factor: 4.530
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