Edward J Filippone1, Andrew J Foy2,3. 1. Clinical Associate Professor of Medicine, Sydney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA. 2. Assistant Professor of Medicine and Public Health Sciences, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA. 3. Penn State Hershey Heart and Vascular Institute, Hershey, PA, USA. E-mail: afoy@hmc.psu.edu.