Paul Gerard Sanfilippo1, Emily Huynh2, Seyhan Yazar2, Alex William Hewitt3, David Anthony Mackey3. 1. Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute, Perth, Australia; Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia. Electronic address: prseye@gmail.com. 2. Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute, Perth, Australia. 3. Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute, Perth, Australia; Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia; School of Medicine, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia.
Abstract
PURPOSE: To characterize and quantify Bruch membrane opening (BMO)-based optic nerve head (ONH) parameters in a large, young and healthy, predominantly white population. DESIGN: Cross-sectional study and reliability analysis. METHODS: The ONH of 1344 predominantly white subjects were imaged with spectral-domain optical coherence tomography (SD-OCT). A customized script, coded in Matlab, was used to manually segment and measure multiple BMO-based parameters of the ONH. Measurements were compared to those obtained with confocal scanning laser ophthalmoscopy (Heidelberg Retina Tomograph; HRT). Regression analysis was performed to assess the relationship between BMO parameters and other ocular and demographic variables. RESULTS: Mean BMO disc and neuroretinal rim (NRR) areas ranged from 0.94 to 4.06 mm(2) (mean 1.77 ± 0.38 mm(2)) and 0.94 to 3.99 mm(2) (mean 1.56 ± 0.31 mm(2)), respectively. When compared to the equivalent HRT measurements, SD-OCT-derived measures differed significantly for all comparable ONH parameters (P < .001). The limits of agreement computed from Bland-Altman plots comparing SD-OCT and HRT measurements showed suboptimal agreement between the techniques. Linear regression analysis demonstrated an effect of ethnicity, axial length, and refractive error on BMO-based parameters. CONCLUSIONS: We have quantified BMO-based parameters in a large cohort of young adults using SD-OCT. These data will be informative in constructing normative profiles for clinical and research purposes in glaucoma diagnosis and management.
PURPOSE: To characterize and quantify Bruch membrane opening (BMO)-based optic nerve head (ONH) parameters in a large, young and healthy, predominantly white population. DESIGN: Cross-sectional study and reliability analysis. METHODS: The ONH of 1344 predominantly white subjects were imaged with spectral-domain optical coherence tomography (SD-OCT). A customized script, coded in Matlab, was used to manually segment and measure multiple BMO-based parameters of the ONH. Measurements were compared to those obtained with confocal scanning laser ophthalmoscopy (Heidelberg Retina Tomograph; HRT). Regression analysis was performed to assess the relationship between BMO parameters and other ocular and demographic variables. RESULTS: Mean BMO disc and neuroretinal rim (NRR) areas ranged from 0.94 to 4.06 mm(2) (mean 1.77 ± 0.38 mm(2)) and 0.94 to 3.99 mm(2) (mean 1.56 ± 0.31 mm(2)), respectively. When compared to the equivalent HRT measurements, SD-OCT-derived measures differed significantly for all comparable ONH parameters (P < .001). The limits of agreement computed from Bland-Altman plots comparing SD-OCT and HRT measurements showed suboptimal agreement between the techniques. Linear regression analysis demonstrated an effect of ethnicity, axial length, and refractive error on BMO-based parameters. CONCLUSIONS: We have quantified BMO-based parameters in a large cohort of young adults using SD-OCT. These data will be informative in constructing normative profiles for clinical and research purposes in glaucoma diagnosis and management.
Authors: Haomin Luo; Hongli Yang; Stuart K Gardiner; Christy Hardin; Glen P Sharpe; Joseph Caprioli; Shaban Demirel; Christopher A Girkin; Jeffrey M Liebmann; Christian Y Mardin; Harry A Quigley; Alexander F Scheuerle; Brad Fortune; Balwantray C Chauhan; Claude F Burgoyne Journal: Invest Ophthalmol Vis Sci Date: 2018-05-01 Impact factor: 4.799
Authors: Kathleen I C Dyer; Paul G Sanfilippo; Seyhan Yazar; Jamie E Craig; Alex W Hewitt; John P Newnham; David A Mackey; Samantha S Y Lee Journal: Transl Vis Sci Technol Date: 2022-07-08 Impact factor: 3.048
Authors: Samantha Sze-Yee Lee; Gareth Lingham; Seyhan Yazar; Paul G Sanfilippo; Jason Charng; Fred K Chen; Alex W Hewitt; Fletcher Ng; Christopher Hammond; Leon M Straker; Peter R Eastwood; Stuart MacGregor; Kathryn A Rose; Robyn M Lucas; Jeremy A Guggenheim; Seang-Mei Saw; Minas T Coroneo; Mingguang He; David A Mackey Journal: BMJ Open Date: 2020-03-25 Impact factor: 2.692