BACKGROUND: Previous studies reported an association of diabetes mellitus (DM) with TB susceptibility. Many studies were retrospective, had weak diagnostic criteria for DM, and did not assess other comorbidities. The Effects of Diabetes on Tuberculosis Severity (EDOTS) study is addressing these limitations with a longitudinal comparison of patients with TB who are classified as diabetic or normoglycemic according to World Health Organization criteria. We report interim findings after enrolling 159 of a planned 300 subjects. METHODS: A cohort study of patients with TB in South India with DM or normoglycemia defined by oral glucose tolerance test (OGTT) and fasting glucose. Glycohemoglobin (HbA1c), serum creatinine, lipids, and 25-hydroxyvitamin D were measured at enrollment. Patients were monitored monthly during TB treatment, and HbA1c measurement was repeated after 3 months. RESULTS: Of 209 eligible patients, 113 (54.1%) were classified as diabetic, 44 (21.0%) with impaired glucose tolerance, and 52 (24.9%) as normoglycemic. More patients with diabetes were detected by OGTT than by HbA1c. Diabetes was a newly received diagnosis for 37 (32.7%) in the DM group, and their median HbA1c (6.8%) was significantly lower than in those with previously diagnosed DM (HbA1c, 10.4%). Among 129 patients monitored for 3 months, HbA1c declined in all groups, with the greatest difference in patients with a newly received diagnosis of DM. CONCLUSIONS: Early EDOTS study results reveal a strikingly high prevalence of glycemic disorders in South Indian patients with pulmonary TB and unexpected heterogeneity within the patient population with diabetes and TB. This glycemic control heterogeneity has implications for the TB-DM interaction and the interpretation of TB studies relying exclusively on HbA1c to define diabetic status.
BACKGROUND: Previous studies reported an association of diabetes mellitus (DM) with TB susceptibility. Many studies were retrospective, had weak diagnostic criteria for DM, and did not assess other comorbidities. The Effects of Diabetes on Tuberculosis Severity (EDOTS) study is addressing these limitations with a longitudinal comparison of patients with TB who are classified as diabetic or normoglycemic according to World Health Organization criteria. We report interim findings after enrolling 159 of a planned 300 subjects. METHODS: A cohort study of patients with TB in South India with DM or normoglycemia defined by oral glucose tolerance test (OGTT) and fasting glucose. Glycohemoglobin (HbA1c), serum creatinine, lipids, and 25-hydroxyvitamin D were measured at enrollment. Patients were monitored monthly during TB treatment, and HbA1c measurement was repeated after 3 months. RESULTS: Of 209 eligible patients, 113 (54.1%) were classified as diabetic, 44 (21.0%) with impaired glucose tolerance, and 52 (24.9%) as normoglycemic. More patients with diabetes were detected by OGTT than by HbA1c. Diabetes was a newly received diagnosis for 37 (32.7%) in the DM group, and their median HbA1c (6.8%) was significantly lower than in those with previously diagnosed DM (HbA1c, 10.4%). Among 129 patients monitored for 3 months, HbA1c declined in all groups, with the greatest difference in patients with a newly received diagnosis of DM. CONCLUSIONS: Early EDOTS study results reveal a strikingly high prevalence of glycemic disorders in South Indian patients with pulmonary TB and unexpected heterogeneity within the patient population with diabetes and TB. This glycemic control heterogeneity has implications for the TB-DM interaction and the interpretation of TB studies relying exclusively on HbA1c to define diabetic status.
Authors: R M Anjana; R Pradeepa; M Deepa; M Datta; V Sudha; R Unnikrishnan; A Bhansali; S R Joshi; P P Joshi; C S Yajnik; V K Dhandhania; L M Nath; A K Das; P V Rao; S V Madhu; D K Shukla; T Kaur; M Priya; E Nirmal; S J Parvathi; S Subhashini; R Subashini; M K Ali; V Mohan Journal: Diabetologia Date: 2011-09-30 Impact factor: 10.122
Authors: Ciaran Skerry; Michael L Pinn; Natalie Bruiners; Richard Pine; Maria L Gennaro; Petros C Karakousis Journal: J Antimicrob Chemother Date: 2014-05-22 Impact factor: 5.790
Authors: Jotam G Pasipanodya; Scott Jn McNabb; Peter Hilsenrath; Sejong Bae; Kristine Lykens; Edgar Vecino; Guadalupe Munguia; Thaddeus L Miller; Gerry Drewyer; Stephen E Weis Journal: BMC Public Health Date: 2010-05-19 Impact factor: 3.295
Authors: Eun Hye Lee; Jung Mo Lee; Young Ae Kang; Ah Young Leem; Eun Young Kim; Ji Ye Jung; Moo Suk Park; Young Sam Kim; Se Kyu Kim; Joon Chang; Song Yee Kim Journal: Lung Date: 2017-02-09 Impact factor: 2.584
Authors: Matthew J Magee; Argita D Salindri; Nang Thu Thu Kyaw; Sara C Auld; J Sonya Haw; Guillermo E Umpierrez Journal: Curr Diab Rep Date: 2018-08-09 Impact factor: 4.810
Authors: V Mave; S Meshram; R Lokhande; D Kadam; S Dharmshale; R Bharadwaj; A Kagal; N Pradhan; S Deshmukh; S Atre; T Sahasrabudhe; M Barthwal; S Meshram; A Kakrani; V Kulkarni; S Raskar; N Suryavanshi; R Shivakoti; S Chon; E Selvin; A Gupte; A Gupta; N Gupte; J E Golub Journal: Int J Tuberc Lung Dis Date: 2017-12-01 Impact factor: 2.373
Authors: Jose Cadena; Selvalakshmi Rathinavelu; Juan C Lopez-Alvarenga; Blanca I Restrepo Journal: Tuberculosis (Edinb) Date: 2019-05-03 Impact factor: 3.131
Authors: Julia A Critchley; Blanca I Restrepo; Katharina Ronacher; Anil Kapur; Andrew A Bremer; Larry S Schlesinger; Randall Basaraba; Hardy Kornfeld; Reinout van Crevel Journal: Chest Date: 2017-04-20 Impact factor: 9.410
Authors: M J Magee; A D Salindri; U P Gujral; S C Auld; J Bao; J S Haw; H-H Lin; H Kornfeld Journal: Int J Tuberc Lung Dis Date: 2018-11-01 Impact factor: 2.373