Literature DB >> 26972840

The JAK/STAT pathway in obesity and diabetes.

Esteban N Gurzov1,2, William J Stanley1,2, Evan G Pappas1,2, Helen E Thomas1,2, Daniel J Gough3,4.   

Abstract

Diabetes mellitus are complex, multi-organ metabolic pathologies characterized by hyperglycemia. Emerging evidence shows that the highly conserved and potent JAK/STAT signaling pathway is required for normal homeostasis, and, when dysregulated, contributes to the development of obesity and diabetes. In this review, we analyze the role of JAK/STAT activation in the brain, liver, muscle, fat and pancreas, and how this affects the course of the disease. We also consider the therapeutic implications of targeting the JAK/STAT pathway in treatment of obesity and diabetes.
© 2016 Federation of European Biochemical Societies.

Entities:  

Keywords:  JAK/STAT signaling pathway; adipose tissue; brain; cytokines; diabetes; hormones; liver; muscle; obesity; pancreas

Mesh：

Substances：

Year:  2016        PMID： 26972840     DOI： 10.1111/febs.13709

Source DB:  PubMed          Journal:  FEBS J        ISSN： 1742-464X            Impact factor:   5.542


  60 in total

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