| Literature DB >> 26972823 |
Paul Lee1, Ron Bova2, Lynne Schofield3, Wendy Bryant4, William Dieckmann5, Anthony Slattery6, Matt A Govendir7, Louise Emmett6, Jerry R Greenfield8.
Abstract
High abundance of brown adipose tissue (BAT) is linked to lower glycaemia in humans, leading to the belief that BAT may protect against diabetes. The relationship between BAT glucose utilization and systemic glucose homeostasis has not been defined. In this paper we have characterized glycaemic excursions and BAT thermogenic responses in human brown adipocytes, BAT explants, and healthy adults through supraclavicular temperature profiling, revealing their circadian coupling in vivo and in vitro, orchestrated by UCP1, GLUT4, and Rev-erbα biorhythms. Extent of glycated haemoglobin also correlated positively with environmental temperature among community-dwelling patients. These data uncover potential crosstalk between BAT and glucose regulatory pathways, evident on cellular, tissue, individual, and population levels, and provide impetus to search for BAT harnessing strategies for therapeutic purposes.Entities:
Keywords: GLUT4; Rev-erb; UCP1; beige adipose; circadian
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Year: 2016 PMID： 26972823 DOI： 10.1016/j.cmet.2016.02.007
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287