Rima A Safadi1, Basma F Quda2, Huda M Hammad3. 1. Associate Professor, Faculty of Dentistry, Jordan University of Science and Technology, Irbid, Jordan. Electronic address: safadir@ksau-hs.edu.sa. 2. Oral Medicine Specialist, Ministry of Health, Zarqa, Jordan. 3. Associate Professor, Faculty of Dentistry, Jordan University of Science and Technology, Irbid, Jordan.
Abstract
OBJECTIVE: To identify cutoff values of markers that correlate with the histopathologic diagnosis of ameloblastic carcinoma (AC) and/or the increased recurrence potential of ameloblastoma (AB). STUDY DESIGN: Immunohistochemical expression (IHCE) of 9 selected markers were investigated in 18 non-recurrent ameloblastomas (NRABs), 6 recurrent ameloblastomas (RABs), and 5 ACs. RESULTS: No significant difference in IHCE of K6, K8, K16, K17, K18, K19, maspin, or syndecan-1 was observed among study groups. α Smooth muscle actin (α-SMA)-positive area in central epithelial cells significantly differentiated between AB and AC (P = .017; t -test). Ki-67 score significantly differentiated between AB and AC (P < .005; t -test) and between AC and RAB (P = .015; ANOVA/post hoc). CONCLUSIONS: Ki-67 score of 75 cells/HPF (ROC curve) is a potential indicator of AC. Clinical recurrence of AB may be predicted by α-SMA expression pattern. Syndecan-1 and α-SMA may indicate a higher aggressive potential of AB when expressed in the stroma.
OBJECTIVE: To identify cutoff values of markers that correlate with the histopathologic diagnosis of ameloblastic carcinoma (AC) and/or the increased recurrence potential of ameloblastoma (AB). STUDY DESIGN: Immunohistochemical expression (IHCE) of 9 selected markers were investigated in 18 non-recurrent ameloblastomas (NRABs), 6 recurrent ameloblastomas (RABs), and 5 ACs. RESULTS: No significant difference in IHCE of K6, K8, K16, K17, K18, K19, maspin, or syndecan-1 was observed among study groups. α Smooth muscle actin (α-SMA)-positive area in central epithelial cells significantly differentiated between AB and AC (P = .017; t -test). Ki-67 score significantly differentiated between AB and AC (P < .005; t -test) and between AC and RAB (P = .015; ANOVA/post hoc). CONCLUSIONS: Ki-67 score of 75 cells/HPF (ROC curve) is a potential indicator of AC. Clinical recurrence of AB may be predicted by α-SMA expression pattern. Syndecan-1 and α-SMA may indicate a higher aggressive potential of AB when expressed in the stroma.
Authors: M Martínez-Martínez; A Mosqueda-Taylor; R Carlos-Bregni; F-R Pires; W Delgado-Azanero; R Neves-Silva; B Aldape-Barrios; O Paes-de Almeida Journal: Med Oral Patol Oral Cir Bucal Date: 2017-05-01
Authors: Callisthenis Yiannis; Massimo Mascolo; Michele Davide Mignogna; Silvia Varricchio; Valentina Natella; Gaetano De Rosa; Roberto Lo Giudice; Cosimo Galletti; Rita Paolini; Antonio Celentano Journal: Int J Environ Res Public Health Date: 2021-04-08 Impact factor: 3.390