Joel B Epstein1,2, Steven B Kupferman3,4, Rachel Zabner5,4, Ali Rejali4, Martin L Hopp4,6, Michael Lill5,4, Dimitrios Tzachanis5,4,7. 1. Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. jepstein@coh.org. 2. Cedars-Sinai Medical Center, Los Angeles, CA, USA. jepstein@coh.org. 3. Section of Oral and Maxillofacial Surgery, UCLA School of Dentistry, Cedars-Sinai Medical Center, Los Angeles, CA, USA. 4. Cedars-Sinai Medical Center, Los Angeles, CA, USA. 5. Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. 6. Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA. 7. Blood and Marrow Transplant Program, University of California, San Diego, CA, USA.
Abstract
PURPOSE: Oral mucormycosis is a rare and high risk of infection in patients following hematopoietic cell transplantation few cases in the literature. We review the literature and present an additional case to emphasize the subtle changes that resulted in positive outcome when diagnosed and managed in a comprehensive transplant team. RESULTS: A patient was diagnosed with gingival mucormycosis on day +25 following a hematopoietic stem cell transplant for lymphoblastic transformation of chronic myeloid leukemia. The patient was diagnosed with minor and nonspecific symptoms and was successfully treated with local dental extraction, a short course of liposomal amphotericin B and 4 months of oral posaconazole. CONCLUSIONS: The good outcome of this case highlights the subtle clinical changes that present early in mucormycosis and the importance of early detection and treatment of post-transplant oral infections by an experienced multidisciplinary team.
PURPOSE:Oral mucormycosis is a rare and high risk of infection in patients following hematopoietic cell transplantation few cases in the literature. We review the literature and present an additional case to emphasize the subtle changes that resulted in positive outcome when diagnosed and managed in a comprehensive transplant team. RESULTS: A patient was diagnosed with gingival mucormycosis on day +25 following a hematopoietic stem cell transplant for lymphoblastic transformation of chronic myeloid leukemia. The patient was diagnosed with minor and nonspecific symptoms and was successfully treated with local dental extraction, a short course of liposomal amphotericin B and 4 months of oral posaconazole. CONCLUSIONS: The good outcome of this case highlights the subtle clinical changes that present early in mucormycosis and the importance of early detection and treatment of post-transplant oral infections by an experienced multidisciplinary team.
Authors: Daniela Metzen; Hartmut Böhm; Marc Zimmermann; Tobias Reuther; Alexander C Kübler; Urs D A Müller-Richter Journal: J Craniomaxillofac Surg Date: 2012-03-16 Impact factor: 2.078
Authors: Nancy E McDermott; John Barrett; Jason Hipp; Maria J Merino; Chyi-Chia Richard Lee; Paige Waterman; Demetrio L Domingo; Thomas J Walsh Journal: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Date: 2010-03
Authors: J Sinkó; J Csomor; R Nikolova; S Lueff; G Kriván; P Reményi; A Bátai; T Masszi Journal: Transpl Infect Dis Date: 2007-07-01 Impact factor: 2.228