Carlos Giuseppucci1, Aixa Reusmann2, Verónica Giubergia3, Carolina Barrias3, Anahi Krüger3, Mónica Siminovich4, Hugo Botto5, Martin Cadario2, Mariano Boglione2, Julieta Strambach2, Marcelo Barrenechea2. 1. Department of General Surgery, Hospital de Pediatría "Prof. Dr. Juan P. Garrahan", Pichincha 1850, Ciudad De Buenos Aires, Argentina. giuse26@gmail.com. 2. Department of General Surgery, Hospital de Pediatría "Prof. Dr. Juan P. Garrahan", Pichincha 1850, Ciudad De Buenos Aires, Argentina. 3. Department of Pulmonology, Hospital de Pediatría "Prof. Dr. Juan P. Garrahan", Pichincha 1850, Ciudad De Buenos Aires, Argentina. 4. Department of Pathology, Hospital de Pediatría "Prof. Dr. Juan P. Garrahan", Pichincha 1850, Ciudad De Buenos Aires, Argentina. 5. Department of Endoscopy, Hospital de Pediatría "Prof. Dr. Juan P. Garrahan", Pichincha 1850, Ciudad De Buenos Aires, Argentina.
Abstract
PURPOSE: Primary lung tumors are rare during childhood and encompass a wide variety of histological types. Each has a different biology and a different therapeutic approach. The aim of this article is to review the experience of a pediatric referral center with this kind of tumors during the last 24 years. METHODS: A retrospective chart review was performed for patients with diagnosis of primary lung tumor between the years 1990-2014. The variables analyzed were age, sex, course of the disease, symptoms, localization, surgery, histology and outcome. RESULTS: Between 1990 and 2014, 38 patients with primary lung tumors were treated at our institution. Age at presentation was 6.6 ± 5.2 years (r 0.91-16.58) and the female:male relationship was 1.37. Inflammatory myofibroblastic lung tumor (n = 13), carcinoid tumor (n = 6) and pleuropulmonary blastoma (n = 6) were the most frequent histological types. Persistent radiographic abnormality was the most frequent presenting sign (34 %). Global mortality was 15.8 % varying according to histology. CONCLUSION: Although the diagnosis of primary lung tumor is rare, the persistence of a radiographic abnormality in spite of adequate treatment for inflammatory processes forces us to evaluate further. The age of the patient is an important factor in the decision of the diagnostic work-up.
PURPOSE:Primary lung tumors are rare during childhood and encompass a wide variety of histological types. Each has a different biology and a different therapeutic approach. The aim of this article is to review the experience of a pediatric referral center with this kind of tumors during the last 24 years. METHODS: A retrospective chart review was performed for patients with diagnosis of primary lung tumor between the years 1990-2014. The variables analyzed were age, sex, course of the disease, symptoms, localization, surgery, histology and outcome. RESULTS: Between 1990 and 2014, 38 patients with primary lung tumors were treated at our institution. Age at presentation was 6.6 ± 5.2 years (r 0.91-16.58) and the female:male relationship was 1.37. Inflammatory myofibroblastic lung tumor (n = 13), carcinoid tumor (n = 6) and pleuropulmonary blastoma (n = 6) were the most frequent histological types. Persistent radiographic abnormality was the most frequent presenting sign (34 %). Global mortality was 15.8 % varying according to histology. CONCLUSION: Although the diagnosis of primary lung tumor is rare, the persistence of a radiographic abnormality in spite of adequate treatment for inflammatory processes forces us to evaluate further. The age of the patient is an important factor in the decision of the diagnostic work-up.
Authors: P Indolfi; F Casale; M Carli; G Bisogno; V Ninfo; G Cecchetto; S Bagnulo; N Santoro; M Giuliano; M T Di Tullio Journal: Cancer Date: 2000-09-15 Impact factor: 6.860
Authors: Yoav H Messinger; Douglas R Stewart; John R Priest; Gretchen M Williams; Anne K Harris; Kris Ann P Schultz; Jiandong Yang; Leslie Doros; Philip S Rosenberg; D Ashley Hill; Louis P Dehner Journal: Cancer Date: 2014-09-10 Impact factor: 6.860
Authors: Aideen M McInerney-Leo; Hui Yi Chew; Po-Ling Inglis; Paul J Leo; Shannon R Joseph; Caroline L Cooper; Satomi Okano; Tim Hassall; Lisa K Anderson; Rayleen V Bowman; Michael Gattas; Jessica E Harris; Mhairi S Marshall; Janet G Shaw; Lawrie Wheeler; Ian A Yang; Matthew A Brown; Kwun M Fong; Fiona Simpson; Emma L Duncan Journal: Hum Mol Genet Date: 2021-11-30 Impact factor: 6.150