Literature DB >> 26971630

Combinatorial Antigen Targeting: Ideal T-Cell Sensing and Anti-Tumor Response.

Maria Themeli1, Michel Sadelain2.   

Abstract

T cells expressing chimeric antigen receptors (CARs) are a formidable platform for the study and application of synthetic biology approaches to study customized and flexible control of cellular functions. Recent reports in the journal Cell provide a new twist on combinatorial antigen targeting, profiting from the singular cleavage and signaling of the Notch receptor to conditionally express CARs.
Copyright © 2016 Elsevier Ltd. All rights reserved.

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Year:  2016        PMID： 26971630      PMCID： PMC4994806          DOI： 10.1016/j.molmed.2016.02.009

Source DB:  PubMed          Journal:  Trends Mol Med        ISSN： 1471-4914            Impact factor:   11.951


  12 in total

1.  PD-1- and CTLA-4-based inhibitory chimeric antigen receptors (iCARs) divert off-target immunotherapy responses.

Authors:  Victor D Fedorov; Maria Themeli; Michel Sadelain
Journal:  Sci Transl Med       Date:  2013-12-11       Impact factor: 17.956

2.  Lack of an immune response against the tetracycline-dependent transactivator correlates with long-term doxycycline-regulated transgene expression in nonhuman primates after intramuscular injection of recombinant adeno-associated virus.

Authors:  David Favre; Véronique Blouin; Nathalie Provost; Radec Spisek; Françoise Porrot; Delphine Bohl; Frederic Marmé; Yan Chérel; Anna Salvetti; Bruno Hurtrel; Jean-Michel Heard; Yves Rivière; Philippe Moullier
Journal:  J Virol       Date:  2002-11       Impact factor: 5.103

3.  Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch.

Authors:  Wendy R Gordon; Brandon Zimmerman; Li He; Laura J Miles; Jiuhong Huang; Kittichoat Tiyanont; Debbie G McArthur; Jon C Aster; Norbert Perrimon; Joseph J Loparo; Stephen C Blacklow
Journal:  Dev Cell       Date:  2015-06-04       Impact factor: 12.270

4.  Redirection of genetically engineered CAR-T cells using bifunctional small molecules.

Authors:  Min Soo Kim; Jennifer S Y Ma; Hwayoung Yun; Yu Cao; Ji Young Kim; Victor Chi; Danling Wang; Ashley Woods; Lance Sherwood; Dawna Caballero; Jose Gonzalez; Peter G Schultz; Travis S Young; Chan Hyuk Kim
Journal:  J Am Chem Soc       Date:  2015-02-24       Impact factor: 15.419

Review 5.  CAR therapy: the CD19 paradigm.

Authors:  Michel Sadelain
Journal:  J Clin Invest       Date:  2015-09-01       Impact factor: 14.808

Review 6.  Targeting tumours with genetically enhanced T lymphocytes.

Authors:  Michel Sadelain; Isabelle Rivière; Renier Brentjens
Journal:  Nat Rev Cancer       Date:  2003-01       Impact factor: 60.716

7.  Inducible apoptosis as a safety switch for adoptive cell therapy.

Authors:  Antonio Di Stasi; Siok-Keen Tey; Gianpietro Dotti; Yuriko Fujita; Alana Kennedy-Nasser; Caridad Martinez; Karin Straathof; Enli Liu; April G Durett; Bambi Grilley; Hao Liu; Conrad R Cruz; Barbara Savoldo; Adrian P Gee; John Schindler; Robert A Krance; Helen E Heslop; David M Spencer; Cliona M Rooney; Malcolm K Brenner
Journal:  N Engl J Med       Date:  2011-11-03       Impact factor: 91.245

8.  Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors.

Authors:  Leonardo Morsut; Kole T Roybal; Xin Xiong; Russell M Gordley; Scott M Coyle; Matthew Thomson; Wendell A Lim
Journal:  Cell       Date:  2016-01-28       Impact factor: 41.582

9.  Remote control of therapeutic T cells through a small molecule-gated chimeric receptor.

Authors:  Chia-Yung Wu; Kole T Roybal; Elias M Puchner; James Onuffer; Wendell A Lim
Journal:  Science       Date:  2015-09-24       Impact factor: 47.728

10.  Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells.

Authors:  Christopher C Kloss; Maud Condomines; Marc Cartellieri; Michael Bachmann; Michel Sadelain
Journal:  Nat Biotechnol       Date:  2012-12-16       Impact factor: 54.908
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  6 in total

Review 1.  Chimeric antigen receptors: driving immunology towards synthetic biology.

Authors:  Michel Sadelain
Journal:  Curr Opin Immunol       Date:  2016-06-30       Impact factor: 7.486

Review 2.  CAR T cell therapy as a promising approach in cancer immunotherapy: challenges and opportunities.

Authors:  Maryam Akhoundi; Mahsa Mohammadi; Seyedeh Saeideh Sahraei; Mohsen Sheykhhasan; Nashmin Fayazi
Journal:  Cell Oncol (Dordr)       Date:  2021-03-24       Impact factor: 6.730

3.  Control of the activity of CAR-T cells within tumours via focused ultrasound.

Authors:  Yiqian Wu; Yahan Liu; Ziliang Huang; Xin Wang; Zhen Jin; Jiayi Li; Praopim Limsakul; Linshan Zhu; Molly Allen; Yijia Pan; Robert Bussell; Aaron Jacobson; Thomas Liu; Shu Chien; Yingxiao Wang
Journal:  Nat Biomed Eng       Date:  2021-08-12       Impact factor: 29.234

Review 4.  New Chimeric Antigen Receptor Design for Solid Tumors.

Authors:  Yuedi Wang; Feifei Luo; Jiao Yang; Chujun Zhao; Yiwei Chu
Journal:  Front Immunol       Date:  2017-12-22       Impact factor: 7.561

Review 5.  Chimeric Antigen Receptor T Cell Therapy for Solid Tumors: Current Status, Obstacles and Future Strategies.

Authors:  Benjamin Heyman; Yiping Yang
Journal:  Cancers (Basel)       Date:  2019-02-06       Impact factor: 6.639

Review 6.  Engineering CAR T cells for enhanced efficacy and safety.

Authors:  Yiqian Wu; Ziliang Huang; Reed Harrison; Longwei Liu; Linshan Zhu; Yinglin Situ; Yingxiao Wang
Journal:  APL Bioeng       Date:  2022-01-18
  6 in total

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