Literature DB >> 26971555

Therapeutic effects of three trichothecenes in the silkworm infection assay with Candida albicans.

Ryuji Uchida1, Shingo Namiguchi, Hiroyuki Ishijima, Hiroshi Tomoda.   

Abstract

The silkworm infection assay is a useful method for directly evaluating the in vivo therapeutic effects of drug candidates. In the present study, 3 known trichothecenes, trichodermin, epiisororidin E, and verrucarin A, were evaluated as antifungal agents in the silkworm-Candida albicans assay. Trichodermin and epiisororidin E yielded effective therapeutic effects, while verrucarin A exhibited no efficacy in this assay system. These results strongly suggest that trichodermin and epiisororidin E are the lead compounds for developing a new antifungal agent.

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Year:  2016        PMID： 26971555     DOI： 10.5582/ddt.2016.01013

Source DB:  PubMed          Journal:  Drug Discov Ther        ISSN： 1881-7831


  8 in total

1.  Synergistic effects of vancomycin and β-lactams against vancomycin highly resistant Staphylococcus aureus.

Authors:  Fumiaki Tabuchi; Yasuhiko Matsumoto; Masaki Ishii; Keita Tatsuno; Mitsuhiro Okazaki; Tomoaki Sato; Kyoji Moriya; Kazuhisa Sekimizu
Journal:  J Antibiot (Tokyo)       Date:  2017-02-15       Impact factor: 2.649

Review 2.  An Update on Candida tropicalis Based on Basic and Clinical Approaches.

Authors:  Diana L Zuza-Alves; Walicyranison P Silva-Rocha; Guilherme M Chaves
Journal:  Front Microbiol       Date:  2017-10-13       Impact factor: 5.640

Review 3.  Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms.

Authors:  Patrick Van Dijck; Jelmer Sjollema; Bruno P Cammue; Katrien Lagrou; Judith Berman; Christophe d'Enfert; David R Andes; Maiken C Arendrup; Axel A Brakhage; Richard Calderone; Emilia Cantón; Tom Coenye; Paul Cos; Leah E Cowen; Mira Edgerton; Ana Espinel-Ingroff; Scott G Filler; Mahmoud Ghannoum; Neil A R Gow; Hubertus Haas; Mary Ann Jabra-Rizk; Elizabeth M Johnson; Shawn R Lockhart; Jose L Lopez-Ribot; Johan Maertens; Carol A Munro; Jeniel E Nett; Clarissa J Nobile; Michael A Pfaller; Gordon Ramage; Dominique Sanglard; Maurizio Sanguinetti; Isabel Spriet; Paul E Verweij; Adilia Warris; Joost Wauters; Michael R Yeaman; Sebastian A J Zaat; Karin Thevissen
Journal:  Microb Cell       Date:  2018-06-14

Review 4.  Bioactive Peptides Against Fungal Biofilms.

Authors:  Karen G N Oshiro; Gisele Rodrigues; Bruna Estéfani D Monges; Marlon Henrique Cardoso; Octávio Luiz Franco
Journal:  Front Microbiol       Date:  2019-10-04       Impact factor: 5.640

5.  Identification of Membrane-Bound Lytic Murein Transglycosylase A (MltA) as a Growth Factor for Francisella novicida in a Silkworm Infection Model.

Authors:  Takemasa Nakamura; Takashi Shimizu; Fumiya Inagaki; Shoma Okazaki; Shib Shankar Saha; Akihiko Uda; Kenta Watanabe; Masahisa Watarai
Journal:  Front Cell Infect Microbiol       Date:  2021-01-22       Impact factor: 5.293

6.  A Bombyx mori Infection Model for Screening Antibiotics against Staphylococcus epidermidis.

Authors:  Aurora Montali; Francesca Berini; Alessio Saviane; Silvia Cappellozza; Flavia Marinelli; Gianluca Tettamanti
Journal:  Insects       Date:  2022-08-19       Impact factor: 3.139

7.  Symbiosis with Francisella tularensis provides resistance to pathogens in the silkworm.

Authors:  Jin Suzuki; Akihiko Uda; Kenta Watanabe; Takashi Shimizu; Masahisa Watarai
Journal:  Sci Rep       Date:  2016-08-10       Impact factor: 4.379

8.  Effect of Vitamin A on Listeria monocytogenes Infection in a Silkworm Model.

Authors:  Yussaira Castillo; Jin Suzuki; Kenta Watanabe; Takashi Shimizu; Masahisa Watarai
Journal:  PLoS One       Date:  2016-09-26       Impact factor: 3.240
  8 in total

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