Jun Xin1, Quanmei Ma2, Qiyong Guo3, Hongzan Sun4, Shaomin Zhang5, Changping Liu6, Wei Zhai7. 1. Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, PR China. Electronic address: xinjun69@189.cn. 2. Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, PR China. Electronic address: quanmeima@qq.com. 3. Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, PR China. Electronic address: guoqy@sj-hospital.org. 4. Department of Nuclear Medicine, Shengjing Hospital of China Medical University, Shenyang, Liaoning, PR China. Electronic address: sunhongzan@sina.com. 5. Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, PR China. Electronic address: zhangshaomin@gmail.com. 6. Department of Nuclear Medicine, Shengjing Hospital of China Medical University, Shenyang, Liaoning, PR China. Electronic address: liucp@sj-hospital.org. 7. Department of Nuclear Medicine, Shengjing Hospital of China Medical University, Shenyang, Liaoning, PR China. Electronic address: zhaiw@sj-hospital.org.
Abstract
OBJECTIVE: Integrated positron emission tomography/magnetic resonance imaging (PET/MRI) scanners provide combined MR-based anatomic and metabolic image information. The aim of this study was to evaluate qualitative and quantitative diagnostic performance of PET/MR with (18)fluoro-2-deoxyglucose ((18)F-FDG) using a diagnostic MR sequence in patients with abdominal and pelvic tumors, compared to positron emission tomography/computed tomography (PET/CT). MATERIALS AND METHODS: Forty five patients underwent a single-injection ((18)F-FDG), dual-imaging protocol including whole-body PET/CT and subsequent regional PET/MR hybrid imaging. A regional PET/MR scan followed the PET/CT. Images from both modalities were analyzed using a 3-point scale for PET/CT and PET/MR image quality, image alignment, and lesion visibility on PET images. PET-CT/PET-MR functional and anatomical correlation was analyzed. RESULTS: A total of 66 lesions were studied, from which 63 were identified using PET/CT and 59 were identified using PET/MR. The (18)F-FDG PET images had good diagnostic quality (P<0.001); alignment was found to be excellent in PET/MR data as well as PET/CT data (P=0.102), and there was no difference in lesion visibility (P=0.18). The average rating score regarding anatomical correlation for PET-positive lesions was 2.75 for combined MR sequence images and 2.04 for CT, with a significant difference (P=0.317), Standard uptake value (SUV) for focal lesions had excellent correlation (SUVmax/mean: R=0.948/0.948); furthermore, the SUVmean of background organs combined, bone marrow and the muscle tissue showed good correlation (R=0.329/0.398/0.298). No correlations were found in the liver and spleen. CONCLUSIONS: PET/MR with diagnostic MR sequence was able to detect abdominal and pelvic lesions and had good image quality compared to PET/CT. SUVmax and SUVmean values in focal lesions, and the SUVmean of background organs generally correlated well in abdominal and pelvic oncology patients examined using PET/CT and PET/MRI.
OBJECTIVE: Integrated positron emission tomography/magnetic resonance imaging (PET/MRI) scanners provide combined MR-based anatomic and metabolic image information. The aim of this study was to evaluate qualitative and quantitative diagnostic performance of PET/MR with (18)fluoro-2-deoxyglucose ((18)F-FDG) using a diagnostic MR sequence in patients with abdominal and pelvic tumors, compared to positron emission tomography/computed tomography (PET/CT). MATERIALS AND METHODS: Forty five patients underwent a single-injection ((18)F-FDG), dual-imaging protocol including whole-body PET/CT and subsequent regional PET/MR hybrid imaging. A regional PET/MR scan followed the PET/CT. Images from both modalities were analyzed using a 3-point scale for PET/CT and PET/MR image quality, image alignment, and lesion visibility on PET images. PET-CT/PET-MR functional and anatomical correlation was analyzed. RESULTS: A total of 66 lesions were studied, from which 63 were identified using PET/CT and 59 were identified using PET/MR. The (18)F-FDG PET images had good diagnostic quality (P<0.001); alignment was found to be excellent in PET/MR data as well as PET/CT data (P=0.102), and there was no difference in lesion visibility (P=0.18). The average rating score regarding anatomical correlation for PET-positive lesions was 2.75 for combined MR sequence images and 2.04 for CT, with a significant difference (P=0.317), Standard uptake value (SUV) for focal lesions had excellent correlation (SUVmax/mean: R=0.948/0.948); furthermore, the SUVmean of background organs combined, bone marrow and the muscle tissue showed good correlation (R=0.329/0.398/0.298). No correlations were found in the liver and spleen. CONCLUSIONS: PET/MR with diagnostic MR sequence was able to detect abdominal and pelvic lesions and had good image quality compared to PET/CT. SUVmax and SUVmean values in focal lesions, and the SUVmean of background organs generally correlated well in abdominal and pelvic oncology patients examined using PET/CT and PET/MRI.