Saskia Persoon1, Marie José Kersten2, Laurien M Buffart3, Griet Vander Slagmolen4, Joke W Baars5, Otto Visser6, Annelies Manenschijn7, Frans Nollet8, Mai J M Chinapaw9. 1. Academic Medical Center, University of Amsterdam, Department of Rehabilitation, the Netherlands. Electronic address: s.persoon@amc.uva.nl. 2. Academic Medical Center, University of Amsterdam, Department of Hematology, the Netherlands. Electronic address: m.j.kersten@amc.uva.nl. 3. VU University Medical Center, Department of Epidemiology and Biostatistics and the EMGO+ Institute for Health and Care Research, Amsterdam, the Netherlands. Electronic address: l.buffart@vumc.nl. 4. De Sportartsen Groep, locatie Amsterdam, the Netherlands. Electronic address: g.vanderslagmolen@amc.uva.nl. 5. Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Division of Medical Oncology, Department of Hematology, the Netherlands. Electronic address: j.baars@nki.nl. 6. VU University Medical Center, Department of Hematology, the Netherlands. Electronic address: o.visser@vumc.nl. 7. Isala, Department of Oncology, Dr. Van Heesweg 2, the Netherlands. Electronic address: j.manenschijn@isala.nl. 8. Academic Medical Center, University of Amsterdam, Department of Rehabilitation, the Netherlands. Electronic address: f.nollet@amc.uva.nl. 9. VU University Medical Center, Department of Public and Occupational Health and the EMGO+ Institute for Health and Care Research, the Netherlands. Electronic address: m.chinapaw@vumc.nl.
Abstract
OBJECTIVES: We aimed to examine health-related physical fitness and its demographic and clinical correlates in patients recently treated with autologous stem cell transplantation. DESIGN: Cross-sectional study. METHODS: In 109 patients (multiple myeloma: n=58, lymphoma: n=51, median age: 55, range: 19-67 years) maximal exercise testing was conducted to assess cardiorespiratory fitness (VO2peak). Upper and lower extremity muscle strength were assessed with hand grip- and fixed dynamometry and body composition with whole body DXA scans. In addition, we assessed the patients' demographic and clinical characteristics and examined whether they were associated with health-related physical fitness. RESULTS: VO2peak was 21.7 (5.5) mL/min/kg, 26% below reference values. Muscle strength was also reduced when compared with reference values (upper extremity: 90%, lower extremity: 80%) and 73% of our population was classified as overweight or obese. Being female and being older were significantly associated with a lower cardiorespiratory fitness (gender: β=-2.7, 95%CI=-4.6;-0.7mL/min/kg; age: β=-0.2, 95%CI=-0.3;-0.1mL/min/kg), upper (gender: β=-17.7, 95%CI=-20.1;-15.3kg; age: β=-0.2, 95%CI=-0.3;-0.1kg) and lower (gender: β=-58.3, 95%CI=-73.5;- 43.0Nm; age: β=-1.7, 95%CI=-2.4;-1.1Nm) extremity muscle strength. Patients who were non-smoking (β=-5.3, 95%CI=-8.7;-1.9), women (β=7.2, 95%CI=4.8;9.6) and diagnosed with multiple myeloma (β=4.6, 95%CI=2.2;6.9) had a higher percentage body fat. CONCLUSIONS: The physical fitness deficits in this population indicate the need for targeted interventions. TRIAL REGISTRATION: Netherlands Trial Register - NTR2341.
RCT Entities:
OBJECTIVES: We aimed to examine health-related physical fitness and its demographic and clinical correlates in patients recently treated with autologous stem cell transplantation. DESIGN: Cross-sectional study. METHODS: In 109 patients (multiple myeloma: n=58, lymphoma: n=51, median age: 55, range: 19-67 years) maximal exercise testing was conducted to assess cardiorespiratory fitness (VO2peak). Upper and lower extremity muscle strength were assessed with hand grip- and fixed dynamometry and body composition with whole body DXA scans. In addition, we assessed the patients' demographic and clinical characteristics and examined whether they were associated with health-related physical fitness. RESULTS: VO2peak was 21.7 (5.5) mL/min/kg, 26% below reference values. Muscle strength was also reduced when compared with reference values (upper extremity: 90%, lower extremity: 80%) and 73% of our population was classified as overweight or obese. Being female and being older were significantly associated with a lower cardiorespiratory fitness (gender: β=-2.7, 95%CI=-4.6;-0.7mL/min/kg; age: β=-0.2, 95%CI=-0.3;-0.1mL/min/kg), upper (gender: β=-17.7, 95%CI=-20.1;-15.3kg; age: β=-0.2, 95%CI=-0.3;-0.1kg) and lower (gender: β=-58.3, 95%CI=-73.5;- 43.0Nm; age: β=-1.7, 95%CI=-2.4;-1.1Nm) extremity muscle strength. Patients who were non-smoking (β=-5.3, 95%CI=-8.7;-1.9), women (β=7.2, 95%CI=4.8;9.6) and diagnosed with multiple myeloma (β=4.6, 95%CI=2.2;6.9) had a higher percentage body fat. CONCLUSIONS: The physical fitness deficits in this population indicate the need for targeted interventions. TRIAL REGISTRATION: Netherlands Trial Register - NTR2341.
Authors: Dorothea Clauss; Christine Tjaden; Thilo Hackert; Lutz Schneider; Cornelia M Ulrich; Joachim Wiskemann; Karen Steindorf Journal: Support Care Cancer Date: 2017-04-17 Impact factor: 3.603
Authors: Johanna M van Dongen; Saskia Persoon; Gabrielle Jongeneel; Judith E Bosmans; Marie José Kersten; Johannes Brug; Frans Nollet; Mai J M Chinapaw; Laurien M Buffart Journal: J Cancer Surviv Date: 2019-07-08 Impact factor: 4.442
Authors: Marianne C Prins; Gerben van Hinte; Niek Koenders; Anne Lieke Rondel; Nicole M A Blijlevens; Manon G A van den Berg Journal: Support Care Cancer Date: 2021-06-16 Impact factor: 3.359